Results 171 to 180 of about 1,404,975 (316)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cognitive-psychological mechanisms and decision-making in later life: the role of wealth perception capability. [PDF]

Front Psychol
He X, Zeng X, Jiang T.
europepmc   +1 more source

A matter of Capabilities

, 2016
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openaire   +3 more sources

Re-conceptualising sustainable development on the basis of the capability approach: A model and its difficulties [PDF]

This paper sketches a re-conceptualisation of sustainable development (SD) on the basis of the capability approach (CA). The notion sustainable development was developed as a compromise in a political process and has been re-interpreted (some say ...
Leßmann, Ortrud, Rauschmayer, Felix
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Neurophobia in health profession students and practitioners: a systematic review and synthesis without meta-analysis (SWiM). [PDF]

Neurol Sci
Garces-Arilla S, Collado S, Hidalgo V, Mendez-Lopez M, Fidalgo C.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Developing consensus-based indicators for intensive care unit capacity and capability in South Korea: a modified Delphi study. [PDF]

Acute Crit Care
Lee J, Sung HK, Oh MH, Kim JY, Kim K, Moon JY.   +5 more
europepmc   +1 more source

Developing and agreeing a capability list in the British context: What can be learnt from social survey data on ‘rights’? [PDF]

The paper examines what can be learnt about the 'valuation' of freedoms and opportunities (or capabilities) using a general population social survey data source on values.
Polly Vizard
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source