Results 81 to 90 of about 1,696,478 (301)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
IT DYNAMIC CAPABILITY DEVELOPMENT IN THE CONTEXT OF DATA GENESIS CAPABILITY [PDF]
Dynamic Capabilities are often considered as the factor justifying the different degrees of success of organizations in turbulent environment. However Dynamic Capability development remains a difficult issue to research, with a paucity of work directly ...
Claudio Vitari
core
Overview of Capability-Driven Development Methodology
, 2018 The Capability-Driven Development (CDD) methodology supports development, delivery, and management of organization and information system capabilities.
Stirna, Janis, +2 more
core +1 more source
Sen and the art of educational maintenance: evidencing a capability, as opposed to an effectiveness, approach to schooling [PDF]
, 2012 There are few more widely applied terms in common parlance than ‘capability’. It is used (inaccurately) to represent everything from the aspiration to provide opportunity to notions of innate academic ability, with everything in between claiming ...
Kelly, Anthony
core +1 more source
Knowledge, Attitude and Research Ability of General Physicians and Dentists Graduated from Hamadan University of Medical Sciences [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2005 Introduction: General physicians (GPs) and dentists have to acquire reasonable research capability during academic education in Iran. For this purpose, various educational programs such as: statistics and research methodology course, Health System ...
Mohammad Fallah +4 more
doaj
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
POINT ESTIMATION OF THE PROCESS CAPABILITY INDEX C(pk) [PDF]
, 1995 In this paper point estimation of the process capability index C(pk) is considered. In order to improve on the natural estimator, a simple alternative estimator is proposed and its mean square error is evaluated ...
Nagata, Yasushi
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Social Inclusion, 2018 This study looks at the equality challenges and opportunities for women with disabilities in low and middle income countries (LMICs) to participate and succeed in education, employment and motherhood.
Belaynesh Tefera +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source