Operationalising Senian capability approach by modelling human development
: In this paper we model sustainable human development as intended in Sen’s capability approach in a system dynamic framework. Our purpose is to verify the variations over time of some achieved functionings, due to structural dynamics and to variations ...
Canova, Luciano +6 more
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The foundation of capability modelling: A study of the impact and utilisation of human resources
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research aims at finding a foundation for assessment of capabilities and applying the concept in a human resource selection.
Shekarriz, Mona
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Measuring early childhood development in multiple contexts: the internal factor structure and reliability of the early Human Capability Index in seven low and middle income countries. [PDF]
BMC Pediatr, 2019 Sincovich A +5 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
A study of process capability index using Bayesian approach under different prior
, 2010 碩士隨著全球化的競爭激烈，以及生活水準的提高所帶來消費者對於產品的品質有更進一步的認識與要求的。因此，生產者必須更重視品質管理，以致於能達到或者超過消費者的需求，以提高與同行的競爭力。由於製程能力指標能夠客觀的表現出製程是否有能力製造出符合消費者所需的產品品質。近幾年來，製程能力指標發展逐漸成熟常被製造業品管上廣大的運用。目前最常使用的製程能力指標 、 、 及 等，而本研究的目的在於針對Chan et al.(1988)等學者所提出的製程能力指標 來進行信賴區間長度的估計 ...
曾國裕; Tzeng, Guo-yu
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Identification of key process areas in the production on an e-capability maturity model for UK construction organisations [PDF]
, 2010 Uptake of e-procurement by construction organisations has been slow (Martin, 2008). Positive e-business achievements in other industries, point towards the potential for the construction industry to accomplish similar results.
Eadie, Robert +3 more
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