Results 51 to 60 of about 333,390 (298)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Measuring the contribution of extractive industries to local development : the case of oil companies in Nigeria [PDF]

Extractive industries face two main challenges in terms of CSR and poverty reduction : 1) recognize that societal activity is part of their core business ; 2) take part in socio-economic projects that contribute to their stakeholders' empowerment and not
Abdou Kâ Diongue, Cécile Renouard, Gaël Giraud   +2 more
core   +3 more sources

Process Capability Evaluation Using Capability Indices as a Part of Statistical Process Control

Mathematics
This study aims to highlight the importance of a systematic approach to process capability assessment and the importance of following a sequence of steps. Statistical process control provides several different ways of assessing process capability.
Marta Benková, Dagmar Bednárová, Gabriela Bogdanovská   +2 more
doaj   +1 more source

Technical Improvement in Revolution Control Expressed through Process Capability Indices

Communications, 2014
In today's competitive environment, it is essential that the company has a set of key indicators reflecting its credible performance. Modern concepts of measuring corporate performance emphasize the need for not only financial but also non-financial ...
Jozef Futo, Lenka Landryova, Vladena Baranova   +2 more
doaj   +1 more source

Bootstrapping Vector-valued Process Capability Indices [PDF]

Communications for Statistical Applications and Methods, 2003
In actual manufacturing industries, process capability analysis often entails characterizing or assessing processes or products based on more than one engineering specification or quality characteristic. Since these characteristics are related, it is a risky undertaking to represent variation of even a univariate characteristic by a single index ...
Joong-Jae Cho, Byoung-Sun Park
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Application of HYDRUS (2D/3D) for Predicting the Influence of Subsurface Drainage on Soil Water Dynamics in a Rainfed-Canola Cropping System [PDF]

, 2018
The HYDRUS (2D/3D) model was applied to investigate the probable effects of different subsurface drainage systems on the soil water dynamics under a rainfed-canola cropping system in paddy fields.
Ajdari, Cameira, Cote, Crevoisier, Darzi-Naftchali, Darzi-Naftchali, Doltra, Feddes, Fernández, Garg, Genuchten, Jafari-Talukolaee, Janssen, Karandish, Karandish, Lazarovitch, Li, Li, Mubarak, Neitsch, Nishat, Ogino, Panigrahi, Parchami-Araghi, Phogat, Rahil, Ramos, Sander, Sander, Siyal, Skaggs, Tafteh, Tan, Tan, Tournebize, Wagenet, Wang, Wessolek, Šimůnek, Šimůnek   +39 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Capability of meteorological drought indices for detecting soil moisture droughts

Journal of Hydrology: Regional Studies, 2017
Study region: Eastern Australia Study focus: Long-term monitoring of soil moisture is a time- and cost-intensive challenge. Therefore, meteorological drought indices are commonly used proxies of periods of significant soil moisture deficit.
Devanmini Halwatura, Neil McIntyre, Alex M. Lechner, Sven Arnold   +3 more
doaj   +1 more source

Testing capability indices for manufacturing processes with asymmetric tolerance limits and measurement errors [PDF]

International Journal of Metrology and Quality Engineering, 2011
Most research works related to process capability indices assume no gauge measurement errors. However, such an assumption inadequately reflects real situations even when advanced measuring instruments are employed.
Grau D.
doaj   +1 more source