Results 51 to 60 of about 517 (162)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Data Management Maturity Model—Process Dimensions and Capabilities to Leverage Data-Driven Organizations Towards Industry 5.0

Applied System Innovation
Data-driven organizations aim to control business decisions based on data. However, despite significant investments in digitalization, studies show that many organizations continue to face challenges in fully realizing the benefits of data.
Lara Pörtner, Andreas Riel, Benedikt Schmidt, Marcel Leclaire, Robert Möske   +4 more
doaj   +1 more source

Practices and Techniques for Engineering Process Capability Models

CLEI Electronic Journal, 2010
Software Process Improvement, based on a Maturity Level or a Process Capability Profile, from a Capability Maturity Model or an ISO/IEC 15504-based model, is well established in the software industry as a successful practical means for improving software
Clenio F. Salviano, Márcia R. M. Martinez, Alessandra Zoucas, Marcello Thiry   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Research on the construction of standard digital capability maturity model for grid enterprise

Dianxin kexue
The digitization of standards is increasingly becoming a core trend in both international and domestic development. To achieve transformation and upgrading, enterprises need to scientifically analyze and evaluate their capabilities in standard ...
XU Haiqing, WANG Sining, WEI Zhifeng, GAO Bingqiang, XIA Baobing, ZHAO Zhenxia   +5 more
doaj   +2 more sources

Research on the intelligent capability maturity and evolution logic of open-pit coal mines

Gong-kuang zidonghua
Existing studies on the construction of intelligent open-pit coal mines have primarily focused on areas such as overall planning, basic architecture, and the evaluation of the completeness of construction content. However, there has been limited research
WANG Zhongxin, TIAN Fengliang, SUN Xin, GUO Xiaosong, HUANG Junting, WANG Lei, ZHANG Zhongwen, ZHAO Guangzhi, SONG Bo, ZENG Xiangyu   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Using Marketing Capability Maturity Model to Measure Marketing Processes at Iran Transfo Corporation

تحقیقات بازار یابی نوین, 2011
In this study marketing maturity model has been used in Iran Transfo Corporation. For this purpose, the five levels process maturity model has been applied.
Arman Ahmadizad, Seyyed Mojtaba Akhavan Hejazi, Amirhossein Sabourtinat   +2 more
doaj   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source