Eupomatenoid‐5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis
Leishmania spp. are protozoa responsible for leishmaniasis, a neglected disease that kills up to 50,000 people every year. Current therapies mainly rely on antimonial drugs that are inadequate because of their poor efficacy and safety and increased drug resistance. An urgent need exists to find new and more affordable drugs.
Francielle Pelegrin Garcia +5 more
wiley +1 more source
Abstract The Ediacaran–Cambrian (∼635–539 Ma) geomagnetic field is characterized by unusually high reversal rates and markedly weakened field strength. Estimates of these reversal frequencies can reveal key aspects of deep Earth dynamics and their potential influence on surface environments and early complex life.
J. W. L. Afonso +12 more
wiley +1 more source
A tetracarbonyl tungsten complex bearing a bis‐triazolylidene ligand exhibits excellent catalytic activity in the acceptorless dehydrogenative coupling of 1‐phenylethanol and 2‐aminobenzyl alcohol to form 2‐phenylquinoline with H2 evolution. Mechanistic investigations combining experimental and DFT studies reveal the unprecedented base‐promoted ...
Beatriz Garcia +2 more
wiley +1 more source
Mollinedia is one of the richest genera of Monimiaceae, with approximately 60 species. In Brazil, 46 species of the genus occur, most of them in the Atlantic Forest. Mollinedia dolichotricha and Mollinedia ruschii are species endemic to the Atlantic Forest and described in the last decade.
Danilo Alvarenga Zavatin +4 more
wiley +1 more source
Hydroxyalkyne–Bithiophene Derivatives: Synthesis and Antileishmanial Activity
Novel bithiophene derivatives with activity against Leishmania amazonensis were synthesized. All compounds exhibited good bioavailability in silico, and among them, BT‐1 was the most active, inducing redox imbalance in promastigotes. ABSTRACT Leishmaniasis is one of the most important neglected tropical diseases, prevalent in underdeveloped or ...
Rayanne Regina Beltrame Machado +8 more
wiley +1 more source
The Rapid Recovery of a Caatinga Dry Forest is Mediated by Disturbance‐Adapted Species
Overall, regenerating and old‐growth forest stands exhibited similar plant diversity across all ontogenetic stages, with a negligible role played by forest stand age, precipitation, and chronic human disturbance. Species exclusively recorded as adults or seeds were mostly dispersed by animals, indicating that several species fail in either dispersing ...
Alexandre S. de Paula +6 more
wiley +1 more source
Ten relevant questions for applying biodiversity offsetting in the Pantanal wetland
Here, we formulated 10 questions that discuss and illustrate how offsetting can be applied to maintain wetland integrity, economic fairness, and biodiversity conservation in the Pantanal and Upper Paraguay River basin (UPRB) We provided examples of offsetting implementation opportunities, analyze spatial compliance deficits, and illustrate requirements
Reinaldo Francisco Ferreira Lourival +37 more
wiley +1 more source
Assessment of Primary Health Care Nurses' Knowledge of Forensic Nursing Competencies. [PDF]
Souza JSR +6 more
europepmc +1 more source
[Implementation of hypertension and diabetes care pathways in two regions of the Brazilian NortheastImplementación de las líneas de cuidado para la hipertensión y la diabetes en dos regiones del nordeste brasileño]. [PDF]
de Abreu-Silva EO +2 more
europepmc +1 more source
Effect of successive tuberculin skin test readings on healthcare professionals' proficiency: an operational observational study in five high-tuberculosis-burden Brazilian municipalities, 2023-2024. [PDF]
Cordeiro DC +6 more
europepmc +1 more source

