Results 121 to 130 of about 344,302 (268)

Advancing IHR capacities in the DRC: findings from the 2022 e-SPAR and NAPHS evaluation. [PDF]

Int Health
Milambo JPM, Benjamin LM.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Relationship Between Physical Fitness and Physical Literacy: Empirical Evidence Linking Two Physical Activity-Health Concepts. [PDF]

Sports Med Open
Derigny T, Maltagliati S, Mekkaoui L, Gandrieau J, Ovigneur H, Schnitzler C, Potdevin F.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Growing up digital: respecting children's evolving capacities in times of change. [PDF]

BMJ Paediatr Open
Subrahmanian R, Aptel C, Herczog M, Jhaveri R, Lansdown G, Mercer R, Mezmur BD, Patel V, Sedletzki V, Teixeira C.   +9 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Development and Implementation of a One Health Point of Entry Checklist in Iraq and Jordan. [PDF]

BMJ Public Health
Linder AG, Hogan KM, Ahmed MJ, Khaleel HA, Kamoona ML, Gazi SM, Elizz NA, Abu-Dalbouh M, Obaidat A, Hussainat M, Al Gobori K, Fogarty AS, Wakefield BC, Nagar A, Vahey R, Hussein TS, Shtaiyat B, Alragaad M, Hailat E, Al-Zadawi KM, Sorrell E.   +20 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Longitudinal Relations Between Representational and Advanced Theory of Mind and Scientific Reasoning From Ages 4 to 7. [PDF]

Dev Sci
Sobel DM, Köksal Ö, Osterhaus C, Bachhuber AM, Sodian B.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source