Results 71 to 80 of about 344,302 (268)
Au-delà de la « précarité » et de son ambivalence : la contribution de l’approche par les capacités
Sociologies, 2011 For this author, the articles on the vulnerability debate adopt points of view that are more complementary than antagonistic. In order to bring out the complementarity, he mobilizes two notions elaborated by Amartya Sen: positional objectivity, according
Jean-Michel Bonvin
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Estimates for capacities and traces of potentials
International Journal of Mathematics and Mathematical Sciences, 1984 It is shown that isoperimetric inequalities, relating measures and capacities, hold for all sets in ℝn if they are valid for all balls. As a corollary, the necessary and sufficient conditions for the continuity of some imbeddings of M. Riesz and Bessel
V. G. Maz'ja, S. P. Preobrazenskii
doaj +1 more source
Generic and action-dependent abilities in Spanish ‘Be capable’
Glossa, 2018 This paper is concerned with the semantics of Spanish ser capaz ‘be capable’ (henceforth SC). Specifically, it aims to account for the distribution SC displays and the range of meanings it expresses in the realm of abilities, viewed as kinds of ...
Elena Castroviejo, Isabel Oltra-Massuet
doaj +2 more sources
Annales de l'Institut Fourier, 2008 We study the relationship between convergence in capacities of plurisubharmonic functions and the convergence of the corresponding complex Monge-Ampère measures. We find one type of convergence of complex Monge-Ampère measures which is essentially equivalent to convergence in the capacity
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Alerta volcánica y erupción del volcán Pichincha en Quito (1998-1999)
Bulletin de l'Institut Français d'Études Andines, 2009 In October 1998, for the first time in the history of the city, a volcanic alert was declared in Quito. The volcano erupted one year later. Crisis analysis demonstrates how the Ecuadorian capital is vulnerable to a volcanic hazard that has been largely ...
Robert D’Ercole +2 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Entre utilitarisme et pessimisme : pour une recherche utile, utilisable et utilisée
VertigO, 2012 There is no day without a book, a debate, a declaration underling the limits of our development : economic limits, ecological limits, and social limits. The growth never creates enough jobs. Global warming is becoming real for everyone.
Jean-Philippe Tonneau +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source