Results 71 to 80 of about 361,420 (264)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Dynamiques dans la gouvernance locale en Inde : le cas des tanks dans la région de Pondichéry
Revue Gouvernance, 2019 Ce texte analyse la mise en oeuvre de principes de « bonne gouvernance » en Inde en questionnant la gestion participative de retenues d’eau (tanks) dans la région de Pondichéry.
Audrey Richard-Ferroudji
doaj +1 more source
Heat Capacities and Thermodynamic Properties of TMPyP
, 2008 Heat Capacities and Thermodynamic Properties of ...
徐芬, 孙立贤, 邱树君
core
Capacities, universality and singularity [PDF]
, 1997 In this paper I criticize Cartwright\u27s analysis of capacities and offer an alternative analysis. I argue that Cartwright\u27s attempt to connect capacities to her condition CC fails because individuals can exercise capacities only in certain contexts.
Glennan, Stuart M.
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
The Möbius transform on symmetric ordered structures and its application to capacities on finite sets [PDF]
Considering a linearly ordered set, we introduce its symmetric version, and endow it with two operations extending supremum and infimum, so as to obtain an algebraic structure close to a commutative ring.
Michel Grabisch
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Au-delà de la « précarité » et de son ambivalence : la contribution de l’approche par les capacités
Sociologies, 2011 For this author, the articles on the vulnerability debate adopt points of view that are more complementary than antagonistic. In order to bring out the complementarity, he mobilizes two notions elaborated by Amartya Sen: positional objectivity, according
Jean-Michel Bonvin
doaj
Estimates for capacities and traces of potentials
International Journal of Mathematics and Mathematical Sciences, 1984 It is shown that isoperimetric inequalities, relating measures and capacities, hold for all sets in ℝn if they are valid for all balls. As a corollary, the necessary and sufficient conditions for the continuity of some imbeddings of M. Riesz and Bessel
V. G. Maz'ja, S. P. Preobrazenskii
doaj +1 more source