Results 61 to 70 of about 26,754 (305)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Quadrature LC VCO with passive coupling and phase combining network [PDF]

, 2016
A circuit and method for generating a signal is disclosed. The circuit includes a set of wide tuning LC tanks, a set of core transistors cross coupled to the set of wide tuning LC tanks, and a combining network coupled to the set of wide tuning LC tanks ...
O, Kenneth K., Sharma, Navneet, Zhang, Jing   +2 more
core   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Analisis Implementasi Fixed Capacitor, SVC, dan STATCOM untuk Perbaikan Performansi Stabilitas Tegangan pada Sistem Petrochina

Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems), 2014
Petrochina adalah salah satu perusahaan tambang minyak yang menggunakan hampir 94% dari pasokan listriknya untuk mencatu beban motor ESP (Electrical Submersible Pump) yang bersifat sangat induktif.
Sigi Syah Wibowo, Hadi Suyono, Rini Nur Hasanah   +2 more
doaj   +1 more source

Analisis Implementasi Fixed Capacitor, SVC, Dan STATCOM Untuk Perbaikan Performansi Stabilitas Tegangan Pada Sistem Petrochina [PDF]

, 2013
Petrochina adalah salah satu Perusahaan tambang minyak yang menggunakan hampir 94% dari pasokan listriknya untuk mencatu beban motor ESP (Electrical Submersible Pump) yang bersifat sangat induktif.
Hasanah, R. N. (Rini), Suyono, H. (Hadi), Wibowo, S. S. (Sigi)   +2 more
core  

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

РОЗРОБКА МЕТОДУ ВИБОРУ ПРИСТРОЇВ КОМПЕНСАЦІЇ РЕАКТИВНОЇ ПОТУЖНОСТІ ЗА УМОВИ МІНІМАЛЬНИХ ЗВЕДЕНИХ ВИТРАТ

Elektrotehnìka ta Elektroenergetika, 2013
Розроблено метод оптимального вибору варіанта розподілу потужності пристроїв компенсації реактивної потужності за умови мінімальних зведених витрат, який дозволяє знизити втрати електроенергії у трансформаторах комплектних трансформаторних підстанцій ...
V. V. Popov, D. I. Komarichina
doaj   +1 more source

Energy Efficiency Analysis of the Discharge Circuit of Caltech Spheromak Experiment [PDF]

, 2010
The Caltech spheromak experiment uses a size A ignitron in switching a 59-μF capacitor bank (charged up to 8 kV) across an inductive plasma load. Typical power levels in the discharge circuit are ~200 MW for a duration of ~10 μs. This paper describes
Bellan, Paul M., Kumar, Deepak, Moser, Auna L.   +2 more
core