BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer
Advanced Science, EarlyView.BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu +12 more
wiley +1 more source
Secure Polar Coding for the Primitive Relay Wiretap Channel. [PDF]
Entropy (Basel), 2021 Athanasakos M, Karagiannidis G.
europepmc +1 more source
Advanced Science, EarlyView.ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang +5 more
wiley +1 more source
Playing With Reality: Emergency Capacity Building Project simulations case study
, 2012 This Emergency Capacity Building (ECB) Project simulation case study focuses on the lessons learnt from implementing the ECB Project multi-agency simulations at the national level between April 2010 and March 2012, using the ECB Simulations ...
Lumsdon, Sarah, Hockaday, David
core +1 more source
Division of Epidemiology and Surveillance Capacity Development 2005 annual report
The Division of Epidemiology and Surveillance Capacity Development (DESCD) 2005 Annual Report is the division\u2019s first annual report, one that reflects the many changes that DESCD and the Centers for Disease Control and Prevention\u2019s (CDC) global
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Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy
Advanced Science, EarlyView.A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan +9 more
wiley +1 more source
A Survey of Lattice-Based Physical-Layer Security for Wireless Systems with <i>p</i>-Modular Lattice Constructions. [PDF]
Entropy (Basel)Khodaiemehr H +5 more
europepmc +1 more source
The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands. [PDF]
Neurosci Biobehav Rev, 2022 Howland JG +3 more
europepmc +1 more source
Absorptive Capacity in Practice-Based Innovation Activities: the Case of Lahti Region, Finland [PDF]
As a consequence of for example agglomeration economies, features such as good reputation and highly-skilled labour force tend to accumulate in university regions.
Vesa Harmaakorpi +2 more
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