Results 91 to 100 of about 4,646,161 (317)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Challenges and opportunities for greater public-private partnership for the implementation of the WHO operational framework for building climate resilient health systems to improve malaria control and elimination in Sub-Saharan Africa: a rapid review

Frontiers in Health Services
The relationship between climate change and malaria is complex, with both predictable and unpredictable aspects. The impacts of climate change may promote mosquito breeding, increase parasite development rates and extend the geographical range of malaria
Sheila Lumumba, Samuel Kamau, Isaac Ntwiga, Josphat Martin Muchangi, Jackline Kiarie, Sarah Kosgei, Moses Mwamburi, George Kimathi   +7 more
doaj   +1 more source

Capacity-cost function.

, 2019
Capacity-cost function (panel A) and capacity per spike (panel B) for the case of coding time window Δ = 100 ms and inhibition scaling factor B = 0.4. The dashed vertical line indicates the cost at which the optimal capacity per spike for the RS neuron ...
Tomas Barta (8067509), Lubomir Kostal (44869)   +1 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Annex 2 - Master List of HEIs

Master List of ...
Centre for Capacity Research
core   +1 more source

Convergence in Capacity

Canadian Mathematical Bulletin, 2012
AbstractIn this note we study the convergence of sequences of Monge–Ampère measures ﹛(ddcus)n﹜, where ﹛us﹜ is a given sequence of plurisubharmonic functions, converging in capacity.
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Bridging the bioinformatics gap: tool selection for decentralized AMR genomic surveillance in Africa

Frontiers in Public Health
Antimicrobial resistance (AMR) poses a significant threat to public health, particularly in low- and middle-income countries where centralized genomic surveillance infrastructure is limited.
Niamh Lacy-Roberts, Christa Twyford Gibson, Pernille Nilsson, Colette J. Weese, Christina Odgaard, Natasia Rebekka Thornval, Rene S. Hendriksen   +6 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Mental capacity including testamentary capacity

Indian Journal of Psychiatry, 2022
Dalal, Pronob Kumar, Tripathi, Adarsh, Kar, Sujita Kumar, Narayan, Choudhary Laxmi, Matkar, Abhay   +4 more
openaire   +2 more sources