Results 241 to 250 of about 10,079,690 (327)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Assessing the capacity of two-flux models to predict the spectral properties of layered materials

, 2016
Mathieu Hébert, Serge Mazauric, Lionel Simonot   +2 more
openalex   +1 more source

Ethnicity, Language Capacity, and Perception of Ethnic-Specific Services Agencies in Asian American and Pacific Islander Communities

, 2003
Julian Chun‐Chung Chow, Paige Wyatt
openalex   +2 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Paradigm shifts in mental health legislation: a comparative analysis of WHO guidelines (2006 & 2023) and implications for future policies. [PDF]

Front Psychiatry
Xue Q, Chen B.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Calculation of ultimate bearing capacity and analysis of bearing characteristics for pile group foundation to underlying offset cave. [PDF]

PLoS One
Zhao Y, Tao J, Li P, Yin L, Zhang Z, Yan H, Zhang W, Ma S, Liu J, Wang H.   +9 more
europepmc   +1 more source

The impact of chronic pain on quality of life among older adults: mediating effects of intrinsic capacity and moderated mediation effects of social support

Yang, Zhilan, Zhao, Huimin, Li, Hongyan, Wu, Bei, Du, Miao, Song, Zeyu, Tian, Ziwei, Jia, Yueyue   +7 more
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Chemical regulation of carbonization enables structure-tailored hard carbon anodes from recycled polypropylene separators. [PDF]

Chem Sci
Wang M, Wang Y, Li N, Zhong Q, Zhu M, Zhang D, Ding S.   +6 more
europepmc   +1 more source