Results 71 to 80 of about 219,591 (309)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The Effect of Geotextile Layers and Configuration on Soil Bearing Capacity
Mathematical Modelling of Engineering Problems, 2021 The term "reinforced soil" refers to a composite material with high tensile-strength components that enhance the soil's tensile strength. One of the most common kinds of geosynthetic fabric utilized for soil reinforcement is geotextiles. This article investigates woven geotextile's potential benefits in enhancing the maximum load-carrying capacity of ...
Lubna Thamer, Hussein Shaia
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Budget Allocation for Permanent and Contingent Capacity under Stochastic Demand. [PDF]
We develop a model of budget allocation for permanent and contingent workforce under stochastic demand. The level of permanent capacity is determined at the beginning of the horizon and is kept constant throughout, whereas the number of temporary workers
Dellaert, Nico +2 more
core
Healthcare Facility Location and Capacity Configuration under Stochastic Demand [PDF]
, 2015 This dissertation addresses two topics. The first topic is strategic dynamic supply chain reconfiguration (DSCR) problem, in which the proposed capacity configuration network is employed in the second topic: healthcare facility location and capacity ...
Han, Xue
core
, 2022 With the increasing installed capacity of wind power, stronger demand for flexible adjustment resources such as energy storage occurs in the power system, and the AC/DC hybrid power grid is the basis for the grid connection, transmission, and ...
Yunyun WU +7 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
EnergiesDeploying renewable generation to replace conventional fossil-fuel-based energy supplies provides an important pathway for the decarbonization of steelmaking plants.
Chamin Geng +6 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source