Results 161 to 170 of about 2,268,216 (315)

Public leadership for gender equality: A framework and capacity development approach for gender transformative policy change. [PDF]

EClinicalMedicine, 2023
Munive A, Donville J, Darmstadt GL.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Indicator-based assessment of capacity development for disaster preparedness in the Indian context. [PDF]

Environ Syst Decis, 2022
George S, Kumar PPA.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Two years of SARS-CoV-2 genomic surveillance capacity development in Guinea. [PDF]

Sci Rep
Magassouba N, Gustani-Buss E, Ifono K, Nelson EV, Camara J, Annibaldis G, Renevey A, Hinzmann J, Hinrichs M, Ryter S, Emua E, Millimono SL, Kolie E, Condé M, Sylla B, Ibrahim N, Mely S, Soubrier H, de Bellocq JG, Escudero-Pérez B, Cuypers LN, Moissonnier E, de Caluwé L, Müller J, Thielebein A, Tomazatos A, Jacobsen C, Pahlmann M, Becker-Ziaja B, Erameh C, Okogbenin S, Koundouno FR, Sidibé Y, Keïta K, Keita MB, Loi G, Kipela MFJM, Ki-Zerbo GA, Dia S, Lemey P, Günther S, Camara A, Soropogui B, Kafetzopoulou LE, Boumbaly S, Duraffour S.   +45 more
europepmc   +1 more source

Factors affecting African postdoctoral researcher capacity development within 'learn-by-doing' international research partnerships: findings from the 'Partnership for Increasing the Impact of Vector Control (PIIVeC)'. [PDF]

BMJ Glob Health, 2023
Amegee Quach J, Valea I, Bates I, Pulford J.   +3 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Principles to guide the effective use of technology to support capacity development in global health partnerships. [PDF]

BMJ Glob Health, 2022
Lynch M, Yoo J, Mukami D, Arian W, Bashford T, Hobden P, Luthra P, Patel M, Ralph N, Winters N, McGrath L, Simms B.   +11 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reframing bioinformatics capacity development in Africa: from training supply to research-driven demand. [PDF]

J Community Genet
Hussein J, Myovela H.
europepmc   +1 more source