Results 91 to 100 of about 6,779,466 (261)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Capacity building assistance (CBA) glossary [PDF]
The Capacity Building Assistance (CBA) Glossary has been developed by the Capacity Building Assistance Provider Network (CPN) in partnership with the Capacity Building Branch (CBB), in the Division of HIV/AIDS Prevention (DHAP) at the Centers for Disease
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Quantitative Assessment of the Economic Viability of Photovoltaic Battery Energy Storage Systems
EnergiesRooftop PV-BESS installations often lose profitability despite policy support to accelerate capacity growth. This paper performs techno-economic analysis to assess the effect of heterogeneity in real-world conditions on the economic viability of ...
Aayesha S. Ahmad +2 more
doaj +1 more source
The Transport Sector : A Laboratory for Good Practices in Capacity Development?
, 2006 As articulated in the Paris Declaration on Aid Effectiveness (2005), country capacity is at the core of sustainable development.
Davis, Deborah
core +1 more source
, 2022 Promoting technological advancements and energy transitions in electricity generation are crucial for achieving carbon reduction goals. Some studies have examined the effectiveness of these measures by analysing the driving forces of “aggregate ...
Shiping Ma, Qianqian Liu, Wenzhong Zhang
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Review of Tidal Lagoon Technology and Opportunities for Integration within the UK Energy System
Inventions, 2017 The number of distributed resources for renewable energy installed worldwide has been increasing rapidly in the last decade, and the great majority of these installations consist of solar panels and wind turbines.
Grazia Todeschini
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source