Results 61 to 70 of about 1,129,724 (343)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Prediction and Optimization of Pile Bearing Capacity Considering Effects of Time

open access: yesMathematics, 2022
Prediction of pile bearing capacity has been considered an unsolved problem for years. This study presents a practical solution for the preparation and maximization of pile bearing capacity, considering the effects of time after the end of pile driving ...
Mohammadreza Khanmohammadi   +2 more
doaj   +1 more source

Production Capacity Optimization with Rough Cut Capacity Planning (RCCP)

open access: yesIOP Conference Series: Materials Science and Engineering, 2020
Abstract One of the factors supporting the company’s success in achieving its goals is the ability to meet demand and provide satisfaction to customers. A musical instrument industry makes products with a make to order system, so that it requires the accuracy and smoothness of the production process to meet the demand in accordance with ...
M Sugarindra, R Nurdiansyah
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Optimal Configuration of Flywheel–Battery Hybrid Energy Storage System for Smoothing Wind–Solar Power Generating Fluctuation

open access: yesEnergies
The integration of energy storage systems is an effective solution to grid fluctuations caused by renewable energy sources such as wind power and solar power.
Shaobo Wen   +4 more
doaj   +1 more source

Optimization of Sorption Capacities and Affinities on the Multiple Sorptive Sites for Illite-rich Clays [PDF]

open access: bronze, 2022
Jeong-Hwan Hwang   +5 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Enumeration optimization of open pit production scheduling based on mobile capacity search domain

open access: yesScientific Reports, 2023
The optimization of open pit mine production scheduling is not only a multistage decision-making problem but also involves space–time dynamic action among multiple factors, which makes it difficult to optimize production capacity, mining sequence, mining
Xiaochuan Xu   +6 more
doaj   +1 more source

Model-based Optimization of Compressive Antennas for High-Sensing-Capacity Applications [PDF]

open access: yes, 2015
This paper presents a novel, model-based compressive antenna design method for high sensing capacity imaging applications. Given a set of design constraints, the method maximizes the sensing capacity of the compressive antenna by varying the constitutive
Martinez-Lorenzo, Jose Angel   +1 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

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