Capacity optimization - Open Access .click

Results 51 to 60 of about 307,350 (217)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source

Capacity optimization and flexibility enhancement of photovoltaic- battery-pumped hybrid storage system

电力工程技术
Pumped hydro storage (PHS) is the most mature storage technology with the largest installed capacity. However, its power regulation rate is slow, and its adjustment flexibility is relatively lacking.
FENG Yizhou, WU Zhi, LI Xinyu, YUAN Bo
doaj +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source

The Modeling and Application of Dynamic Lane Assignment in Urban Areas: A Case Study of Vukovar Street in Zagreb, Croatia

Applied Sciences
Traffic congestion in urban areas presents significant challenges to mobility, road safety, and the overall quality of the urban traffic network. This study presents a simulation-based modeling framework for dynamic lane assignment (DLA) systems designed
Miroslav Vujić, Luka Dedić, Mijo Majstorović +2 more
doaj +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source

Cargo Aircraft Capacity Optimization: A Hybrid Approach Comprising a Genetic Algorithm and Large Neighborhood Search

Applied Sciences
Air transportation has accelerated international trade, and the efficient use of cargo aircraft capacity supports logistics operations, reduces expenses, and benefits the environment.
Gul Durak, Nihan Cetin Demirel
doaj +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source

Capacity Optimization and Rolling Scheduling of Offshore Multi-Energy Coupling Systems

Energies
Increasing penetration of offshore renewable energy has highlighted the challenges posed by strong intermittency, output uncertainty, and insufficient utilization of marine energy resources.
Honggang Fan, Yan Liu, Cui Wang, Wankun Wang +3 more
doaj +1 more source

Optimization of ATSC Mobile Handheld Service Capacity

International Journal of Digital Multimedia Broadcasting, 2013
Mobile TV has become a reality offered on several mobile delivery systems. Among them is the Advanced Television System Committee (ATSC) system for mobile and handheld digital television services, known as ATSC Mobile DTV or ATSC M/H, which has moved ...
Omneya Issa
doaj +1 more source

renewable energy