Results 61 to 70 of about 307,350 (217)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Optimal Sizing of Power and Hydrogen Storage Systems Considering Electrolyzer Efficiency and Start-Up Dynamics

Energies
To reduce renewable output volatility and improve system integration efficiency, this study constructs a coordinated wind–solar–storage–hydrogen framework.
Cancheng Qiu, Zhong Wen, Guofeng He, Ke Zhang, Ziyong Xu   +4 more
doaj   +1 more source

From capacity maximization to flagship train optimization: a novel framework for brand-oriented railway timetabling [PDF]

Railway Sciences
PurposeThis study investigates the impact of flagship trains on high-speed railway capacity utilization and develops a brand value-oriented optimization framework that balances service quality enhancement with operational efficiency.Design/methodology ...
Huizhang Xu
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimization Strategies for Hybrid Energy Storage Systems in Fuel Cell-Powered Vessels Using Improved Droop Control and POA-Based Capacity Configuration

Journal of Marine Science and Engineering
The maritime industry faces significant challenges from energy consumption and air pollution. Fuel cells, especially hydrogen types, offer a promising clean alternative with high energy density and rapid refueling, but their slow dynamic response ...
Xiang Xie, Wei Shen, Hao Chen, Ning Gao, Yayu Yang, Abdelhakim Saim, Mohamed Benbouzid   +6 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Capacity Optimization of Offshore Microgrids Considering Uncertainty and Conditional Risk

Energies
The high-penetration integration of offshore renewable energy introduces significant challenges, including high volatility, randomness, and insufficient energy accommodation, which place higher demands on the planning and operation of offshore integrated
Honggang Fan, Yan Liu, Zipeng Chen, Cui Wang, Wankun Wang   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Charging infrastructure load forecasting models for planning and optimizing technical service bases

Технічна інженерія
The rapid growth of the share of vehicles with electric traction makes it necessary to review approaches to the design and operation of production and technical bases of road transport enterprises.
O.O. Lysenko
doaj   +1 more source

The Secrecy Capacity Optimization Artificial Noise: A New Type of Artificial Noise for Secure Communication in MIMO System

IEEE Access, 2019
In multiple-input multiple-output wireless communication system, artificial noise (AN) is designed to be aligned into the null space of the legitimate channel so that it has no effect on the legitimate channel.
Yebo Gu, Zhilu Wu, Zhendong Yin, Xiaojun Zhang   +3 more
doaj   +1 more source