Results 171 to 180 of about 417,251 (308)

MEASURING FISHING CAPACITY: AN APPLICATION TO IN NORTH PACIFIC GROUNDFISH FISHERIES

open access: yes
This research provides estimates of fishing capacity for the pollock fishery of the Bering Sea and Aleutian Islands using DEA and stochastic frontier techniques.
Felthoven, Ronald G.
core  

Some instability puzzles in Kaleckian models of growth and distribution: A critical survey [PDF]

open access: yes
We tackle the issue of the possible instability of the Kaleckian distribution and growth model and the consequences for the endogeneity of the equilibrium rate of capacity utilization and for the paradox of thrift and the paradox of costs. Distinguishing
Marc Lavoie   +2 more
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Fishing Capacity and Harvest Rules

open access: yes
In this note we consider the choice of optimum fishing capacity for fish stocks that vary at random. In models with stochastic variations of fish stocks, optimum fishing capacity is normally a decision variable separate from fishing effort.
Hannesson, Rognvaldur
core  

Capacity Choice under Uncertainty: The Impact of Market Structure [PDF]

open access: yes
We analyze a market game where firms choose capacities under uncertainty about future market conditions and make output choices after uncertainty has unraveled.
Veronika Grimm, Gregor Zoettl
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Trends in refinery capacity and utilization.

open access: yes
"DOE/RA-0010."Annual covers 2 areas: "Petroleum refineries in the United States" and "Foreign refinery exporting centers"; Dec. 1974- mid-year supplement covers U.S. only.Report year ends June 30.Mode of access: Internet.Vols.
United States. Department of Energy. Office of Oil and Natural Gas.   +4 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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