Results 181 to 190 of about 1,317,542 (308)

Cardiometabolic Mortality and Health System Expansion in Kuwait (2010-2022): A National Time-Series Analysis. [PDF]

J Clin Med
Salman A.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Dynamic demand forecasting and capacity assessment for emergency care system: a hybrid time series and machine learning approach with evidence from Beijing. [PDF]

BMC Health Serv Res
Zhao Y.
europepmc   +1 more source

Zeolites capacity utilization down

Focus on Surfactants, 2003
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

From crisis to recovery: Exploring the demand surge for mental health services in Alberta, Canada-A document-based policy analysis with an illustrative supply-demand simulation (2023-2024). [PDF]

PLOS Ment Health
Adegoke K, Adegoke A, Dawodu D, Bayowa A, Adekoya A, Kayode T, Singh M, Durojaye OA, Aluko AI, Adegoke A.   +9 more
europepmc   +1 more source

Optimizing the long-term operating plan of railway marshalling station for capacity utilization analysis. [PDF]

ScientificWorldJournal, 2014
Zhou W, Yang X, Qin J, Deng L.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Hospital-Level NICU Capacity, Utilization, and 30-Day Outcomes in Texas.

JAMA Netw Open
Goodman DC, Stuchlik P, Ganduglia-Cazaban C, Tyson JE, Leyenaar J, Avritscher EBC, Rysavy M, Gautham KS, Lynch D, Stukel TA, Texas Neonatal Care Research Collaborative.   +10 more
europepmc   +1 more source

Optimized scheduling of integrated energy systems: a multi-dimensional electricity, hydrogen, ammonia, heat synergy approach using the LSDBO-WOA algorithm. [PDF]

Sci Rep
Tu N, Yang J, Yan X, Fan Z.
europepmc   +1 more source