Results 51 to 60 of about 1,304,274 (289)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A Capacity-Utilization-Oriented Stop Planning Approach for High-Speed Railway Network with Stop Distribution Balance

Applied Sciences
Stop planning is aimed to provide proper services for passenger demand, but diverse stop patterns lead to differences in stop density and travel speeds, impacting the utilization of line capacity.
Shuo Zhao, Xinghua Shan, Jinfei Wu, Litao Zhang, Zhenyi Li, Xuying Liu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Capacity and Capacity Utilization in Fishing Industries [PDF]

, 1999
Excess capacity of fishing fleets is one of the most pressing problems facing the world's fisheries and the sustainable harvesting of resource stocks. Considerable confusion persists over the definition and measurement of capacity and capacity utilization in fishing. Fishing capacity and capacity utilization, rather than capital (or effort) utilization,
Kirkley, James E, Squires, Dale
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

PENGUKURAN NAICU PADA SEKTOR INDUSTRI PENGOLAHAN BERDASARKAN DUAL COST CAPACITY UTILIZATION

Buletin Ekonomi Moneter dan Perbankan, 2007
Following the study on the measurement of capacity utilization of manufacturing industries in Indonesia (Tjahjono, Husman, and Sianipar (2005)), this paper estimates the level of NAICU, Non-Accelerating Inflation rate of Capacity Utilization.
Endy Dwi Tjahjono, Jardine Husman, Desthy Sianipar   +2 more
doaj   +1 more source

Capacity Utilization Rates across NFL Stadiums [PDF]

, 2018
Attendance at NFL games has steadily increased for the past half-decade. Teams and the league as a whole have a direct interest in learning what brings fans to the games.
Bennett, Samantha, Williams, Isaac
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Efficiency Analysis of Turkish Container Ports: SFA or DEA?

Verimlilik Dergisi
Purpose: The study compares the efficiency of Turkish container ports using Stochastic Frontier Analysis and Data Envelopment Analysis. It aims to provide comparative insights for enhancing ports' operational performance.
İsmail Yenilmez
doaj   +1 more source