Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas+15 more
wiley +1 more source
Buffalo milk: an essential natural adjuvant
The water buffalo breed known as the Murrah buffalo (Bubalus bubalis) is primarily raised for its milk. It is preserved in the Indian states of Haryana and Punjab, namely in the districts of Bhiwani, Agra, Hisar, Rohtak, Jind, Jhajhar, Fatehabad, Gurgaon,
Oghenerume Lucky Emakpor+9 more
doaj +1 more source
Determining Feasibility and Parameter Values for Compound Orders Based on Transfer Amounts, Liquid Handler Capabilities, and Container Volume Capacities [PDF]
Mark F. Russo, Steven L. Hoffman
openalex +1 more source
Quasi-option value under ambiguity [PDF]
Real investments involving irreversibility and ambiguity embed a positive quasi-option value under ambiguity (q.o.v.a.), which modifies the evaluation of an investment decision involving depletion of natural resources by increasing the value of delaying.
Fulvio Fontini, Marcello Basili
core
Measuring wind plant capacity value [PDF]
Electric utility planners and wind energy researchers pose a common question: What is the capacity value of a wind plant? Tentative answers, which can be phrased in a variety of ways, are based on widely varying definitions and methods of calculation.
openaire +3 more sources
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song+13 more
wiley +1 more source
The Effect of Both Different Light Conditions and the pH Value on the Capacity of Salvinia minima Baker for Removing Cadmium, Lead and Chromium [PDF]
Eugenia J. Olguín+2 more
openalex +1 more source
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam+9 more
wiley +1 more source
Reference values for the physical work capacity on a bicycle ergometer for men – a comparison with a previous study on women [PDF]
Björn Wohlfart, Gholam Reza Farazdaghi
openalex +1 more source
Horses as Sources of Proprietary Information: Commercialization, Conservation, and Compensation Pursuant to the Convention on Biological Diversity [PDF]
Horses indigenous to East and Southeast (E/SE) Asia, including native, landrace, feral, and wild populations, embody valuable genetic diversity. Conservation efforts for animals have largely been driven by humane altruism, with little consideration for ...
Kowalski, Stanley, McClory, Haley
core +1 more source