Results 31 to 40 of about 353,327 (314)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Exploring atitudes towards immigrants in Cape Town, South Africa [PDF]
, 2011 Earlier studies conducted in South Africa suggest that negative attitudes towards immigrants are widespread and driven by resource strain, issues around national identity, and the process of ‘othering’.
Murambiwa, Rutendo
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Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Merchants, commissioners and wardmasters : municipal politics in Cape Town, 1840-1854 [PDF]
, 1986 Bibliography: leaves 260-272.Merchants,Commissioners and Wardmasters: Municipal Politics in Cape Town, 1840-854 explores the social, political and economic changes and conflicts that helped to determine Cape Town's evolution in the mid nineteenth century.
Warren, Digby
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Scientific Reports, 2021 We recently isolated a novel adenylyl cyclase/cAMP phosphodiesterase gene from the liverwort, Marchantia polymorpha. The protein encoded by this gene has a class III adenylyl cyclase (AC) in the C-terminal domain and class I phosphodiesterase (PDE) in ...
Chiaki Yamamoto +5 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Exploring the key socio-economic challenges facing youth refugees in the Western Cape [PDF]
, 2012 Includes abstract.Includes bibliographical references.This study explored the key socio-economic challenges facing youth refugees in the Western Cape. The study was carried out on a purposive sample of twelve youth refugees.
Shawa, Elizabeth HL
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International Journal of Traditional and Complementary Medicine ResearchObjective: The aim of this study was to compare the vasoactive effects of resveratrol, CAPE and silibinin on the basal tone and serotonin (5-HT) induced contractile responses of isolated human umbilical arteries.Material-Method: This study was approved ...
Ayşegül Arzum Karabaş +1 more
doaj +1 more source
Secondary Air Pollutants and Forests — New Perspectives
The Scientific World Journal, 2007 Air pollution has been known to affect forests for over a century, and many of the mechanisms of pollutant deposition and effects have been established, at least for forest trees.
J. Neil Cape
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source