Results 21 to 30 of about 243,790 (263)

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Authentication: A Standard Problem or a Problem of Standards? [PDF]

PLoS Biology, 2016
Reproducibility and transparency in biomedical sciences have been called into question, and scientists have been found wanting as a result. Putting aside deliberate fraud, there is evidence that a major contributor to lack of reproducibility is ...
Amanda Capes-Davis, Richard M Neve
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Uso do Planejamento Estratégico por um Programa de Pós-Graduação com base no Sistema de Avaliação da CAPES [PDF]

, 2006
A partir da emissão da Lei de Diretrizes e Bases da Educação LDB em 1996, o setor educacional brasileiro vem enfrentando uma revolução na flexibilidade e ampliação da oferta de ensino superior, (BRASIL, 1996).
Almeida, Martinho Isnard Ribeiro de, Maccari, Emerson Antoni, Rodrigues, Leonel Cezar, Coimbra, Fabio Claro   +3 more
core  

O papel da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) na Cooperação Brasileira para o Desenvolvimento Internacional (Cobradi) [PDF]

, 2015
The article is dedicated to present the outlay of CAPES with cooperation for international development based on the COBRADI report. The study confirms the relevance of the educational cooperation and the important role of the agency in this process ...
Aveiro, Thais Mere Marques, Thais Mere Marques Aveiro   +1 more
core   +1 more source

Diagnósticos e prescrições de enfermagem para idosos em situação hospitalar

Avances en Enfermería, 2015
Objetivo: Identificar os diagnósticos de enfermagem descritos pela North American Nursing Diagnosis Association mais frequentes entre idosos em situação hospitalar e propor prescrições correlatas para idosos em situação hospitalar.
Luana Nogueira Lira, Silvana Sidney Costa Santos, Danielle Adriane Silveira Vidal, Daiane Porto Gautério, Jamila Geri Tomaschewski-Barlem, Diéssica Roggia Piexak   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

O processo de produção do conhecimento nos PPGs de teologia: da institucionalização à inserção no sistema Capes [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Programa de Pós-Graduação em Educação.Nesta tese, o objetivo foi investigar as induções geradas pelo sistema de avaliação e fomento da Coordenação de ...
Guindani, Evandro Ricardo
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The W-Defense Defended

Ergo, An Open Access Journal of Philosophy
The W-defense is among the most prominent arguments for the principle of alternative possibilities (PAP). Here I offer some considerations in support of the W-defense and respond to what I see as the most forceful objections to it to date. My response to
Justin Capes
doaj   +2 more sources