Results 31 to 40 of about 6,481 (213)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Geographic distribution of Thysanoteuthis rhombus (Cephalopoda, Thysanoteuthidae) on the Brazilian coast [PDF]

open access: yesCheck List, 2014
Data on two female individuals of the diamonback squid, Thysanoteuthis rhombus, are presented with discussion of occurrences along the Brazilian coast.
Carlo Cunha, Luciano Oliveira
doaj   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

O PARFOR NO CONTEXTO DA POLÍTICA NACIONAL DE FORMAÇÃO DE PROFISSIONAIS DO MAGISTÉRIO DA EDUCAÇÃO BÁSICA

open access: yesColloquium Humanarum, 2018
o objetivo deste trabalho é realizar uma breve análise do Plano Nacional de Formação de Professores da Educação Básica (Parfor), instituído em 2009 no âmbito da Política Nacional de Formação de Profissionais do Magistério da Educação Básica, sob ...
Nathanael da Cruz e Silva Neto   +1 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The W-Defense Defended

open access: yesErgo, An Open Access Journal of Philosophy
The W-defense is among the most prominent arguments for the principle of alternative possibilities (PAP). Here I offer some considerations in support of the W-defense and respond to what I see as the most forceful objections to it to date. My response to
Justin Capes
doaj   +2 more sources

Innovación en la Educación Superior: Un Relato de Experiencia

open access: yesRevista Gestión I+D, 2023
El objetivo de esta investigación es relatar prácticas académicas centradas en la innovación en una universidad comunitaria del sur de Brasil. Para ello, realizamos una revisión bibliográfica y un relato de experiencia, de cuño cualitativo, desde las ...
Louise de Quadros da Silva   +3 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

ESTUDOS ETNOBOTÂNICOS E AULAS SOBRE PLANTAS MEDICINAIS NA E.E. MARIA LUIZA DE GUIMARAES MEDEIROS, SÃO JOSÉ DOS CAMPOS - SP

open access: yesRevista UniVap, 2017
Resumo - O presente trabalho objetivou investigar o conhecimento etnobotânico dos alunos da E.E. Maria Luiza de Guimarães Medeiros, localizado na região Norte de São José dos Campos – SP e paralelamente desenvolver aulas práticas com os alunos ...
Elisa Celeste Dreux   +9 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy