Results 61 to 70 of about 39,456 (318)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Capillarity Theory for the Fly-Casting Mechanism

, 2010
Biomolecular folding and function are often coupled. During molecular recognition events, one of the binding partners may transiently or partially unfold, allowing more rapid access to a binding site.
Chavez, Clementi, Clementi, Dunker, Dyson, E. Trizac, Finkelstein, Huang, Huang, Kubelka, Levy, Levy, Levy, Miyashita, Onuchic, Onuchic, P. G. Wolynes, Tompa, To  th-Petro  czy, Whitford, Wolynes, Wright, Wright, Y. Levy, Yang   +24 more
core   +2 more sources

The prescribed mean curvature equation in weakly regular domains [PDF]

, 2018
We show that the characterization of existence and uniqueness up to vertical translations of solutions to the prescribed mean curvature equation, originally proved by Giusti in the smooth case, holds true for domains satisfying very mild regularity ...
A-I Vol’pert, C Gerhardt, C Gerhardt, C Gerhardt, C Scheven, CF Gauss, D Swanson, E Giusti, E Giusti, E Parini, G Anzellotti, G Anzellotti, G Philippis De, G-Q Chen, G-Q Chen, G-Q Chen, G-Q Chen, GE Comi, GE Comi, Gian Paolo Leonardi, Giorgio Saracco, GP Leonardi, H Federer, H Federer, H Federer, KE Lancaster, L Beck, L Simon, L-F Tam, L-F Tam, LA Caffarelli, LA Caffarelli, M Emmer, M Emmer, M Giaquinta, M Miranda, M Miranda, P Concus, P Concus, P Concus, P Concus, PS Laplace, R Finn, R Finn, R Finn, S Maniglia, T Schmidt, T Young, V Maz’ya, WF Pfeffer, WF Pfeffer, WP Ziemer   +51 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Thermodynamic properties and homogeneous nucleation rates for surface-melted physical clusters [PDF]

, 1996
We predict the free energy of van der Waals clusters (Fn) in the surface-melted temperature regime. These free energies are used to predict the bulk chemical potential, surface tension, Tolman length, and vapor pressure of noble gas crystals.
Flagan, Richard C., Goddard, William A., III, McClurg, Richard B.   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Study of sorptivity of self‐compacting concrete with mineral additives

Journal of Civil Engineering and Management, 2006
This work presents the results of a comparative study of the sorptivity, accomplished in mixtures of selfcompacting concrete with different types of additives and a normal concrete compacted by vibration.
Luiz Antonio Pereira de Oliveira, João Paulo de Castro Gomes, Cristiana Nadir Gonilho Pereira   +2 more
doaj   +1 more source

Capillarity problems with nonlocal surface tension energies [PDF]

, 2016
We explore the possibility of modifying the classical Gauss free energy functional used in capillarity theory by considering surface tension energies of nonlocal type.
Maggi, Francesco, Valdinoci, Enrico
core   +3 more sources

Capillarity and Archimedes’ principle [PDF]

Pacific Journal of Mathematics, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
McCuan, John, Treinen, Ray
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source