Results 41 to 50 of about 655,261 (308)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceCapillary Flows of Nematic Liquid Crystal
Crystals, 2020 In this paper we report the new experimental results on the rise of a liquid crystal in flat capillaries with inner photosensitive surfaces. The capillaries with different surface orientations were prepared by the use of the photo-alignment technique ...Dina V. Shmeliova, Sergey V. Pasechnik, Semen S. Kharlamov, Alexandre V. Zakharov, Eugeny P. Pozhidaev, Vadim A. Barbashov, Timofey P. Tkachenko +6 moredoaj +1 more sourceTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more sourceDeciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall +14 morewiley +1 more sourceSkin capillary blood flow in scleroderma [PDF]
Journal of Clinical Investigation, 1971 Skin blood flow was measured by the clearance of radioactive xenon ((133)Xe) injected intracutaneously in eight patients with scleroderma and nine control subjects under conditions of controlled temperature and humidity. Scleroderma patients, on being cooled 1 hr at 18 degrees C, had a rate constant of (133)Xe clearance from the dorsal finger skin ...E C, LeRoy, J A, Downey, P J, Cannonopenaire +2 more sourcesTargeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa +9 morewiley +1 more sourceMycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci +7 morewiley +1 more sourceEffective Rheology of Bubbles Moving in a Capillary Tube
, 2012 We calculate the average volumetric flux versus pressure drop of bubbles
moving in a single capillary tube with varying diameter, finding a square-root
relation from mapping the flow equations onto that of a driven overdamped
pendulum. The calculation is Abelev, B, Adam, J, Adamova, D, Adare, AM, Aggarwal, MM, Agocs, AG, Agostinelli, A, Ahammed, Z, Ahmad, N, Ahn, SU, Akindinov, A, Alaniz, EC, Aleksandrov, D, Alessandro, B, Alici, A, Alkin, A, Alme, J, Alt, T, Altini, V, Altinpinar, S, Altsybeev, I, Andrei, C, Andronic, A, Anguelov, V, Anielski, J, Anson, C, Anticic, T, Antinori, F, Antonioli, P, Aphecetche, L, Appelshauser, H, Arbor, N, Arcelli, S, Arend, A, Armesto, N, Arnaldi, R, Aronsson, T, Arsene, IC, Arslandok, M, Asryan, A, Augustinus, A, Averbeck, R, Avina, EA, Awes, TC, Aysto, J, Azmi, MD, Bach, M, Badala, A, Baek, YW, Bailhache, R, Baillie, OV, Bala, R, Balbastre, GC, Baldisseri, A, Baldit, A, Ban, J, Baral, RC, Barbera, R, Bari, DD, Barile, F, Barnafoldi, GG, Barnby, LS, Barret, V, Barros, GOVD, Barroso, VC, Bartke, J, Basile, M, Bastid, N, Bathen, B, Batigne, G, Batyunya, B, Baumann, C, Bearden, IG, Beck, H, Belikov, I, Bellini, F, Bellwied, R, Belmont-Moreno, E, Bencedi, G, Beole, S, Berceanu, I, Bercuci, A, Berdnikov, Y, Berenyi, D, Bergmann, C, Berzano, D, Betev, L, Bhasin, A, Bhati, AK, Bianchi, L, Bianchi, N, Bianchin, C, Bielcik, J, Bielcikova, J, Bjelogrlic, S, Blanco, F, Blanco, F, Blau, D, Blume, C, Boccioli, M, Bock, N, Bogdanov, A, Boggild, H, Bogolyubsky, M, Boldizsar, L, Bombara, M, Book, J, Borel, H, Borissov, A, Bornec, YL, Bose, S, Bossu, F, Botje, M, Bottger, S, Boyer, B, Braidot, E, Braun-Munzinger, P, Bregant, M, Breitner, T, Browning, TA, Broz, M, Brun, R, Bruna, E, Bruno, GE, Budnikov, D, Buesching, H, Bufalino, S, Bugaiev, K, Busch, O, Bustamante, RTJ, Buthelezi, Z, Caffarri, D, Cahuantzi, MR, Cai, X, Caines, H, Camerini, P, Carena, F, Carena, W, Carminati, F, Caro, AD, Castellanos, JC, Castro, XS, Casula, EAR, Cataldo, GD, Catanescu, V, Cavicchioli, C, Cepila, J, Cerello, P, Cervantes, IM, Chang, B, Chapeland, S, Charvet, JL, Chattopadhyay, S, Chattopadhyay, S, Chawla, I, Cherney, M, Cheshkov, C, Cheynis, B, Chiavassa, E, Chinellato, DD, Chochula, P, Chojnacki, M, Christakoglou, P, Christensen, CH, Christiansen, P, Chujo, T, Chung, SU, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Coccetti, F, Colamaria, F, Colella, D, Collaboration, ALICE, Constantin, P, Contin, G, Contreras, JG, Corchero, MAD, Cormier, TM, Corral, GH, Cortese, P, Cosentino, MR, Costa, F, Cotallo, ME, Crescio, E, Crochet, P, Cuautle, E, Cunqueiro, L, Cuveland, JD, Dainese, A, Dalsgaard, HH, Danu, A, Das, D, Das, I, Das, K, Dash, A, Dash, S, Davalos, AM, De, S, Delagrange, H, Deloff, A, Demanov, V, Denes, E, Deppman, A, Diaz, AC, Dietel, T, Divia, R, Djuvsland, O, Dobrin, A, Dobrowolski, T, Dominguez, I, Don, CKK, Donigus, B, Dordic, O, Driga, O, Dubey, AK, Ducroux, L, Dupieux, P, Elia, D, Emschermann, D, Engel, H, Erasmo, GD, Erdal, HA, Espagnon, B, Estienne, M, Esumi, S, Evans, D, Eyyubova, G, Fabris, D, Faivre, J, Falchieri, D, Falco, AD, Fantoni, A, Fasel, M, Fearick, R, Fedunov, A, Fehlker, D, Feldkamp, L, Felea, D, Feofilov, G, Ferreiro, EG, Ferretti, A, Ferretti, R, Ferroli, RB, Figiel, J, Figueredo, MAS, Filchagin, S, Filho, EPDO, Filho, NC, Finogeev, D, Fionda, FM, Fiore, EM, Floris, M, Foertsch, S, Foka, P, Fokin, S, Fragiacomo, E, Fragkiadakis, M, Frankenfeld, U, Fuchs, U, Furget, C, Gaardhoje, JJ, Gagliardi, M, Gago, A, Gallio, M, Gangadharan, DR, Ganoti, P, Garabatos, C, Garcia, GM, Garcia-Solis, E, Garishvili, I, Gerhard, J, Germain, M, Geuna, C, Gheata, A, Gheata, M, Ghidini, B, Ghosh, P, Gianotti, P, Giglio, CD, Girard, MF, Girard, MR, Giubellino, P, Gladysz-Dziadus, E, Glassel, P, Godoy, DAMD, Gomez, R, Gonzalez-Trueba, LH, Gonzalez-Zamora, P, Gorbunov, S, Goswami, A, Gotovac, S, Grabski, V, Graczykowski, LK, Grajcarek, R, Grelli, A, Grigoras, A, Grigoras, C, Grigoriev, V, Grigoryan, A, Grigoryan, S, Grinyov, B, Grion, N, Gros, P, Grosse-Oetringhaus, JF, Grossiord, JY, Grosso, R, Gruttola, DD, Guber, F, Guernane, R, Guerzoni, B, Guevara, PLD, Guilbaud, M, Gulbrandsen, K, Gunji, T, Gupta, A, Gupta, R, Gutbrod, H, Gutierrez, CG, Haaland, O, Hadjidakis, C, Haiduc, M, Haller, BV, Hamagaki, H, Hamar, G, Han, BH, Hanratty, LD, Hansen, A, Harmanova, Z, Harris, JW, Hartig, M, Hasegan, D, Hatzifotiadou, D, Hayrapetyan, A, Heckel, ST, Heide, M, Helstrup, H, Herghelegiu, A, Hernandez, JFC, Herrmann, N, Hetland, KF, Hicks, B, Hille, PT, Hippolyte, B, Horaguchi, T, Hori, Y, Hristov, P, Hrivnacova, I, Huang, M, Huber, S, Humanic, TJ, Hwang, DS, Ichou, R, Ilkaev, R, Ilkiv, I, Inaba, M, Incani, E, Innocenti, GM, Innocenti, PG, Ippolitov, M, Irfan, M, Ivan, C, Ivanov, A, Ivanov, M, Ivanov, V, Ivanytskyi, O, Jacholkowski, A, Jacobs, PM, Jancurova, L, Jang, HJ, Jangal, S, Janik, MA, Janik, R, Jayarathna, PHSY, Jena, S, Jirden, L, Jones, PG, Jung, H, Jusko, A, Kaidalov, AB, Kakoyan, V, Kalcher, S, Kalinak, P, Kalisky, M, Kalliokoski, T, Kalweit, A, Kanaki, K, Kang, JH, Kaplin, V, Karampatsos, LX, Karavichev, O, Karavicheva, T, Karpechev, E, Kazantsev, A, Kebschull, U, Keidel, R, Khan, MM, Khan, P, Khan, SA, Khanzadeev, A, Kharlov, Y, Kileng, B, Kim, B, Kim, DJ, Kim, DW, Kim, JH, Kim, JS, Kim, M, Kim, S, Kim, SH, Kim, T, Kirsch, S, Kisel, I, Kiselev, S, Kisiel, A, Klay, JL, Klein, J, Klein-Bosing, C, Kliemant, M, Kluge, A, Knichel, ML, Knospe, AG, Koch, K, Kohler, MK, Kolk, NVD, Kolojvari, A, Kondratiev, V, Kondratyeva, N, Konevskikh, A, Korneev, A, Kour, R, Kowalski, M, Kox, S, Kral, J, Kralik, I, Kramer, F, Kraus, I, Krawutschke, T, Krelina, M, Kretz, M, Krivda, M, Krizek, F, Krus, M, Kryshen, E, Krzewicki, M, Kucheriaev, Y, Kuhn, C, Kuijer, PG, Kurashvili, P, Kurepin, A, Kurepin, AB, Kuryakin, A, Kushpil, S, Kushpil, V, Kvaerno, H, Kweon, MJ, Kwon, Y, Lakomov, I, Langoy, R, Lara, C, Lara, CEP, Lardeux, A, Lazzeroni, C, Lea, R, Lee, KS, Lee, SC, Leeuwen, MV, Lefevre, F, Lehnert, J, Leistam, L, Lenhardt, M, Lenti, V, Leon, H, Levai, P, Lezama, EP, Liberto, SD, Lien, J, Lietava, R, Lindal, S, Lindenstruth, V, Lippmann, C, Lisa, MA, Liu, L, Loenne, PI, Loggins, VR, Loginov, V, Lohn, S, Lohner, D, Loizides, C, Loo, KK, Lopez, X, Lovhoiden, G, Lu, XG, Luettig, P, Lunardon, M, Luo, J, Luparello, G, Luquin, L, Luzzi, C, Ma, K, Ma, R, Madagodahettige-Don, DM, Maevskaya, A, Mager, M, Mahapatra, DP, Maire, A, Majumdar, AKD, Majumdar, MRD, Mal'Kevich, D, Malaev, M, Maldonado, IC, Malinina, L, Malzacher, P, Mamonov, A, Manceau, L, Mangotra, L, Manko, V, Manso, F, Manzari, V, Mao, Y, Marchisone, M, Marco, ND, Mares, J, Margagliotti, GV, Margotti, A, Marin, A, Markert, C, Martashvili, I, Martinengo, P, Martinez, MI, Martynov, Y, Mas, A, Masciocchi, S, Masera, M, Masoni, A, Masoodi, AA, Massacrier, L, Mastromarco, M, Mastroserio, A, Matthews, ZL, Matyja, A, Mauro, AD, Mayani, D, Mayer, C, Mazer, J, Mazzoni, MA, Meddi, F, Meethaleveedu, GK, Menchaca-Rocha, A, Meres, M, Miake, Y, Milano, L, Milosevic, J, Mischke, A, Mishra, AN, Miskowiec, D, Mitu, C, Mlynarz, J, Mohanty, AK, Mohanty, B, Molina, RA, Molnar, L, Monteno, M, Montero, AJR, Montes, E, Montoya, CAC, Monzon, IL, Moon, T, Morales, YC, Morando, M, Moretto, S, Morsch, A, Muccifora, V, Mudnic, E, Muhuri, S, Muller, H, Munhoz, MG, Munoz, GT, Musa, L, Musso, A, Nandi, BK, Nania, R, Nappi, E, Nattrass, C, Naumov, NP, Navin, S, Nayak, TK, Nazarenko, S, Nazarov, G, Nedosekin, A, Nezza, PD, Nicassio, M, Nielsen, BS, Niida, T, Nikolaev, S, Nikolic, V, Nikulin, S, Nikulin, V, Nilsen, BS, Nilsson, MS, Noferini, F, Nomokonov, P, Nooren, G, Novitzky, N, Nyanin, A, Nyatha, A, Nygaard, C, Nystrand, J, Ochirov, A, Oeschler, H, Oh, S, Oh, SK, Oleniacz, J, Oppedisano, C, Orduna, DC, Ortona, G, Oskarsson, A, Ostrowski, P, Otwinowski, J, Ovrebekk, G, Oyama, K, Ozawa, K, Pachmayer, Y, Pachr, M, Padilla, F, Pagano, P, Paic, G, Painke, F, Pajares, C, Pal, S, Pal, SK, Palaha, A, Palmeri, A, Palomo, LV, Papikyan, V, Pappalardo, GS, Park, WJ, Pasquale, SD, Passfeld, A, Pastircak, B, Patalakha, DI, Paticchio, V, Pavlinov, A, Pawlak, T, Pedrosa, FBDS, Peitzmann, T, Peresunko, D, Perez, JM, Perini, D, Perrino, D, Peryt, W, Pesci, A, Peskov, V, Pestov, Y, Petracek, V, Petran, M, Petris, M, Petrov, P, Petrovici, M, Petta, C, Piano, S, Piccotti, A, Pikna, M, Pillot, P, Pinazza, O, Pinsky, L, Pitz, N, Piuz, F, Piyarathna, DB, Ploskon, M, Pluta, J, Pocheptsov, T, Pochybova, S, Podesta-Lerma, PLM, Poghosyan, MG, Polak, K, Polichtchouk, B, Pop, A, Porteboeuf-Houssais, S, Pospisil, V, Potukuchi, B, Prasad, SK, Preghenella, R, Prino, F, Pruneau, CA, Pshenichnov, I, Puchagin, S, Puddu, G, Pulvirenti, A, Punin, V, Putis, M, Putschke, J, Quercigh, E, Qvigstad, H, Rachevski, A, Rademakers, A, Radomski, S, Raiha, TS, Rak, J, Rakotozafindrabe, A, Ramello, L, Raniwala, R, Raniwala, S, Rasanen, SS, Rascanu, BT, Rathee, D, Read, KF, Real, JS, Redlich, K, Reichelt, P, Reicher, M, Renfordt, R, Reolon, AR, Reshetin, A, Rettig, F, Revol, JP, Reyes, AR, Reygers, K, Riccati, L, Ricci, RA, Richert, T, Richter, M, Riedler, P, Riegler, W, Riggi, F, Rinella, GA, Rocca, PL, Roed, K, Rohr, D, Rohrich, D, Roman, VC, Romeo, GC, Romita, R, Ronchetti, F, Rooij, RD, Rosnet, P, Rossegger, S, Rossi, A, Roukoutakis, F, Roy, C, Roy, P, Rui, R, Ryabinkin, E, Rybicki, A, Sadovsky, S, Safarik, K, Sahoo, R, Sahu, PK, Saini, J, Sakaguchi, H, Sakai, S, Sakata, D, Salazar, SA, Salgado, CA, Salzwedel, J, Sambyal, S, Samsonov, V, Sanchez, EDC, Sandor, L, Sandoval, A, Sano, M, Sano, S, Santo, R, Santoro, R, Sarkamo, J, Scapparone, E, Scarlassara, F, Scharenberg, RP, Schiaua, C, Schicker, R, Schmidt, C, Schmidt, HR, Schreiner, S, Schuchmann, S, Schukraft, J, Schutz, Y, Schwarz, K, Schweda, K, Scioli, G, Scomparin, E, Scott, PA, Scott, R, Segato, G, Selyuzhenkov, I, Senyukov, S, Seo, J, Serci, S, Serradilla, E, Sevcenco, A, Sgura, I, Shabetai, A, Shabratova, G, Shahoyan, R, Sharma, N, Sharma, S, Shigaki, K, Shimomura, M, Shtejer, K, Sibiriak, Y, Siciliano, M, Sicking, E, Siddhanta, S, Siemiarczuk, T, Silvermyr, D, Silvestre, C, Simonetti, G, Singaraju, R, Singh, R, Singha, S, Sinha, BC, Sinha, T, Sitar, B, Sitta, M, Skaali, TB, Skjerdal, K, Smakal, R, 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Venaruzzo, M, Vercellin, E, Vergara, S, Vernekohl, DC, Vernet, R, Verweij, M, Vickovic, L, Viesti, G, Vikhlyantsev, O, Vilakazi, Z, Villar, EC, Vinogradov, A, Vinogradov, L, Vinogradov, Y, Virgili, T, Viyogi, YP, Vodopyanov, A, Voloshin, K, Voloshin, S, Volpe, G, Vranic, D, Vrlakova, J, Vulpescu, B, Vyushin, A, Vyvre, PV, Wagner, B, Wagner, V, Wan, R, Wang, D, Wang, M, Wang, Y, Wang, Y, Watanabe, K, Wessels, JP, Westerhoff, U, Wiechula, J, Wikne, J, Wilde, M, Wilk, A, Wilk, G, Williams, MCS, Windelband, B, Yang, H, Yang, S, Yasnopolskiy, S, Yi, J, Yin, Z, Yokoyama, H, Yoo, IK, Yoon, J, Yu, W, Yuan, X, Yushmanov, I, Zach, C, Zampolli, C, Zaporozhets, S, Zarochentsev, A, Zavada, P, Zaviyalov, N, Zbroszczyk, H, Zelnicek, P, Zetina, LM, Zgura, IS, Zhalov, M, Zhang, X, Zhou, D, Zhou, F, Zhou, Y, Zhu, X, Zichichi, A, Zimmermann, A, Zinovjev, G, Zoccarato, Y, Zynovyev, M +972 morecore +1 more source
