Results 111 to 120 of about 2,618,344 (297)

Optimal capital investment under uncertainty: An extension [PDF]

open access: yes
This paper develops a model for optimal capital investment in continuous time when both existing and new capital stocks are subject to uncertainty. The model is generalized to allow for large and infrequent changes in the dynamics of the capital stock ...
Hyeon-seung Huh   +2 more
core  

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

open access: yesAdvanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu   +12 more
wiley   +1 more source

Ecosystem Services in Decision Making: Time to Deliver [PDF]

open access: yes, 1998
Over the past decade, efforts to value and protect ecosystem services have been promoted by many as the last, best hope for making conservation mainstream – attractive and commonplace worldwide.
Salzman, James   +8 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

open access: yesAdvanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu   +11 more
wiley   +1 more source

Natural Resources and Economic Growth: What Is the Connection? [PDF]

open access: yes
This paper reviews the relationship between natural resources and economic growth, and stresses how natural capital tends to crowd out foreign capital, social capital, human capital, andphysical capital, thereby impeding economic growth across countries ...
Thorvaldur Gylfason
core  

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

open access: yesAdvanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang   +4 more
wiley   +1 more source

Catastrophic Shocks and Capital markets: A Comparative Analysis by Disaster and Sector [PDF]

open access: yes
This paper provides an analysis of the impact of natural, industrial and terrorist disasters on the Australian capital market using the Box and Tiao intervention analysis and the data on daily returns in the following ten market sectors: consumer ...
Valadkhani, Abbas, Worthington, Andrew
core  

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

open access: yesAdvanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan   +19 more
wiley   +1 more source

Variation Characteristics of Land Use Change Within the Beijing–Tianjin–Hebei Region During 1985–2022

open access: yesLand
Land use change generally varies greatly among functional zones in a large area. This study reveals land use change characteristics across seven functional zones in the Beijing–Tianjin–Hebei region during 1985–2022 based on the latest land use planning ...
Huijuan Wang   +3 more
doaj   +1 more source

Mozambique and natural disasters: human capital under threat [PDF]

open access: yes
This paper assesses the effect of a sequence of natural disasters on children’s health that hit Mozambique at the start of the 21st Century. The disasters in question were the floods of 2000 and the droughts of the years 2002 and 2003.
Prado C. Alfaiate, Jorge
core   +1 more source

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