Results 31 to 40 of about 2,650 (160)
The Journal of Poultry Science, 2018 Calpain 3 (CAPN3), also known as p94, is associated with multiple production traits in domestic animals. However, the molecular characteristics of the CAPN3 gene and its expression profile in goose tissues have not been reported.
Hengyong Xu +8 more
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CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)
International Journal of Molecular Medicine, 2021 Calpains are a family of Ca2+‑dependent cysteine proteases that participate in various cellular processes. Calpain 3 (CAPN3) is a classical calpain with unique N‑terminus and insertion sequence 1 and 2 domains that confer characteristics such as rapid autolysis, Ca2+‑independent activation and Na+ activation of the protease.
Chen, Lin +5 more
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Анналы клинической и экспериментальной неврологии, 2021 Introduction. Limb-girdle muscular dystrophy (LGMD) includes more than 30 forms caused by mutations in genes located on autosomes. The most common form is calpain-3-related LGMD, with autosomal recessive inheritance pattern (OMIM 253600).
Inna V. Sharkova +4 more
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An eccentric calpain, CAPN3/p94/calpain-3
Biochimie, 2016 Calpains are Ca(2+)-regulated proteolytic enzymes that are involved in a variety of biological phenomena. Calpains process substrates by limited proteolysis to modulate various protein functions in the cell, and are thus called "modulator proteases." CAPN3, previously called p94 or calpain-3, has unique features that are not found in any of the other ...
Ono, Yasuko +4 more
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Journal of Molecular Biology, 2013 CAPN3/p94/calpain-3 is a skeletal-muscle-specific member of the calpain protease family. Multiple muscle cell functions have been reported for CAPN3, and mutations in this protease cause limb-girdle muscular dystrophy type 2A. Little is known about the molecular mechanisms that allow CAPN3 to be so multifunctional. One hypothesis is that the very rapid
Ono, Yasuko +7 more
openaire +2 more sources
Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge. [PDF]
Immunol Cell BiolIn this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Foyle KL +6 more
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Stem Cells International, 2023 Large numbers of Calpain 3 (CAPN3) mutations cause recessive forms of limb-girdle muscular dystrophy (LGMD2A/LGMDR1) with selective atrophy of the proximal limb muscles.
Lampros Mavrommatis +9 more
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Clinical and Pathological Heterogeneity of Korean Patients with CAPN3 Mutations
Yonsei Medical Journal, 2016 This study was designed to investigate the characteristics of Korean patients with calpainopathy.Thirteen patients from ten unrelated families were diagnosed with calpainopathy via direct or targeted sequencing of the CAPN3 gene. Clinical, mutational, and pathological spectra were then analyzed.Nine different mutations, including four novel mutations ...
Park, Hyung Jun +10 more
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Skeletal Muscle, 2017 Background Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle.
Mehmet E. Yalvac +9 more
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A New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 Tenderness is the most important meat quality trait, which is determined by intracellular environment and extracellular matrix. Particularly, specific protein degradation and protein modification can disrupt the architecture and integrity of muscle cells
Ting Lian, Linjie Wang, Yiping Liu
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