Results 1 to 10 of about 37,520 (214)
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
doaj +2 more sources
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Xiaoning Bi +2 more
exaly +3 more sources
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. [PDF]
PLoS ONE, 2012 Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on
Daniela M Santos +4 more
doaj +1 more source
Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology
Neurobiology of Disease, 2021 Calpain has been proposed to play a critical role in the development of epilepsy. Here we used conditional calpain-2 knock-out (C2CKO) mice in a C57/Bl6 background and a selective calpain-2 inhibitor to analyze the role of calpain-2 in epilepsy ...
Yubin Wang +5 more
doaj +1 more source
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice.
Venkateswaran Subramanian +5 more
doaj +1 more source
Biology Open, 2020 Calpain-3 (CAPN3) is a muscle-specific type of calpain whose protease activity is triggered by Ca2+. Here, we developed CAPN3 sensor probes (SPs) to detect activated-CAPN3 using a fluorescence/Förster resonance energy transfer (FRET) technique.
Koichi Ojima +6 more
doaj +1 more source
Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. [PDF]
PLoS ONE, 2011 Calpain proteases drive intracellular signal transduction via specific proteolysis of multiple substrates upon Ca(2+)-induced activation. Recently, dUTPase, an enzyme essential to maintain genomic integrity, was identified as a physiological calpain ...
Zoltán Bozóky +6 more
doaj +1 more source
Biomolecules, 2023 Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP ...
Yujie Dong +6 more
doaj +1 more source
Changes in neurodegeneration-related miRNAs in brains from CAPN1−/− mice
BBA Advances, 2021 Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs.
Wenyue Su +3 more
doaj +1 more source
Calpain: the regulatory point of myocardial ischemia-reperfusion injury
Frontiers in Cardiovascular Medicine, 2023 Calpain is a conserved cysteine protease readily expressed in several mammalian tissues, which is usually activated by Ca2+ and with maximum activity at neutral pH.
Guo-Yang Liu +20 more
doaj +1 more source