Results 1 to 10 of about 49,188 (286)
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
doaj +3 more sources
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Yubin Wang +2 more
exaly +4 more sources
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice.
Venkateswaran Subramanian +5 more
doaj +4 more sources
Role of Calpain in Apoptosis [PDF]
Cell Journal, 2011 Apoptosis, a form of programmed cell death that occurs under physiologicalas well as pathological conditions, is characterized by morphological and biochemicalfeatures.
Hamid Reza Momeni
doaj +3 more sources
Malaria Journal, 2013 Background With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs. Calpain inhibitor, ALLN, is proposed to inhibit parasite proliferation by suppressing haemoglobin degradation.
Soh Byoung +9 more
doaj +2 more sources
Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice [PDF]
FASEB BioAdvancesAbdominal adiposity is associated with increased risk of abdominal aortic aneurysm (AAA) development. Calpains are non‐lysosomal calcium‐dependent cysteine proteases that are highly expressed in human and experimental AAAs.
Ana Clara Frony +6 more
doaj +2 more sources
Calpain Protects the Heart from Hemodynamic Stress
Journal of Biological Chemistry, 2011 Calpains make up a family of Ca(2+)-dependent intracellular cysteine proteases that include ubiquitously expressed μ- and m-calpains. Both are heterodimers consisting of a distinct large catalytic subunit (calpain 1 for μ-calpain and calpain 2 for m ...
Manabu Taneike +2 more
exaly +2 more sources
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. [PDF]
PLoS ONE, 2012 Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on
Daniela M Santos +4 more
doaj +1 more source
Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology
Neurobiology of Disease, 2021 Calpain has been proposed to play a critical role in the development of epilepsy. Here we used conditional calpain-2 knock-out (C2CKO) mice in a C57/Bl6 background and a selective calpain-2 inhibitor to analyze the role of calpain-2 in epilepsy ...
Yubin Wang +5 more
doaj +1 more source
Biology Open, 2020 Calpain-3 (CAPN3) is a muscle-specific type of calpain whose protease activity is triggered by Ca2+. Here, we developed CAPN3 sensor probes (SPs) to detect activated-CAPN3 using a fluorescence/Förster resonance energy transfer (FRET) technique.
Koichi Ojima +6 more
doaj +1 more source