Results 1 to 10 of about 2,856 (161)

Single-Nucleotide Polymorphisms in Calpastatin (CAST) and Micro-Calpain (CAPN1) Genes Influencing Meat Tenderness in Crossbred Beef Cattle in Thailand [PDF]

Veterinary Sciences
This study investigated single-nucleotide polymorphisms (SNPs) within the CAPN1 316, CAPN1 4751, and CAST 2959 markers using high-resolution melting (HRM) analysis to predict meat tenderness in crossbred beef cattle.
Thanathip Thaloengsakdadech, Supawit Triwutanon, Preeda Lertwatcharasarakul, Nitipong Homwong, Theera Rukkwamsuk   +4 more
doaj   +2 more sources

Differential regulation of the calpain–calpastatin complex by the L-domain of calpastatin

Biochimica Et Biophysica Acta - Molecular Cell Research, 2014
Here we demonstrate that the presence of the L-domain in calpastatins induces biphasic interaction with calpain. Competition experiments revealed that the L-domain is involved in positioning the first inhibitory unit in close and correct proximity to the calpain active site cleft, both in the closed and in the open conformation.
Roberta De Tullio, Marco Pedrazzi, Mónica Averna   +2 more
exaly   +5 more sources

Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation [PDF]

Frontiers in Molecular Biosciences
Glioblastoma (GBM) is the most malignant brain tumor, characterized by cell heterogeneity comprising stem cells (GSCs) responsible for aggressiveness. The calpain/calpastatin (calp/cast) proteolytic system is involved in critical physiological processes ...
Sonia Spinelli, Sonia Spinelli, Federica Barbieri, Federica Barbieri, Monica Averna, Tullio Florio, Tullio Florio, Marco Pedrazzi, Beatrice F. Tremonti, Michela Capraro, Roberta De Tullio   +10 more
doaj   +2 more sources

Role of Calpains in Uremia-Related Functional and Structural Muscle Changes: Protective Effect of Calpastatin Overexpression [PDF]

Cells
Sarcopenia, the progressive loss of muscle mass and strength, is a common complication in patients with chronic kidney disease (CKD). This condition arises from a combination of factors including reduced physical activity, insufficient protein intake ...
Elena Gutiérrez-Calabrés, Sofía Campillo, Elena Alcalde-Estévez, Paula Cuevas-Delgado, Coral Barbas, Sergio García-Villoria, Alba Silvestre-Vargas, Mercedes Griera, Sergio de Frutos, María P. Ruiz-Torres, Diego Rodríguez-Puyol, Laura Calleros   +11 more
doaj   +2 more sources

Different Proteins as Biomarkers for Sac Shrinkage After Endovascular Aortic Repair of Abdominal Aortic Aneurysms [PDF]

Journal of Cardiovascular Development and Disease
Background: This study aims to identify circulating biomarkers by using proteomic analysis associated with sac shrinkage or expansion in patients undergoing endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAAs).
Alexander Zimmermann, Daniela Reitnauer, Yankey Yundung, Anna-Leonie Menges, Lorenz Meuli, Jaroslav Pelisek, Benedikt Reutersberg   +6 more
doaj   +2 more sources

Temperament Upregulates Mitochondrial Enzymes and Negatively Affects Myofibrillar Fragmentation in Beef of Excitable Bos taurus indicus Cattle [PDF]

Metabolites
Background: Bos taurus indicus cattle is known to be temperamental and to produce beef with greater variability in terms of quality compared to beef of Bos taurus taurus.
Patricia Maloso Ramos, Eduardo Francisquine Delgado, Ana Cláudia da Silva, Nara Regina Brandão Cônsolo, Vinicius Laerte Silva Herreira, João Marcos Bovetto de Campos Valim, Fernanda Maria Marins Ocampos, Luiz Alberto Colnago, Saulo da Luz e Silva   +8 more
doaj   +2 more sources

Calpastatin (CAST) Gene Polymorphism in Tsigai and Merinoland Sheep Breeds Under Conditions of the Republic of Crimea [PDF]

BIO Web of Conferences, 2021
The article presents the results of studying the Calpastatin (CAST) gene polymorphism in Tsigai (n = 23) and Merinoland sheep breed (n = 13). The purpose of the research.
Uppe Veronika, Kuevda Tatiana, Zubochenko Denis, Usmanova Elena, Ostapchuk Pavel   +4 more
doaj   +1 more source

Phosphorylation of Calpastatin Negatively Regulates the Activity of Calpain

Life, 2023
Tenderness is an important characteristic of meat quality. Calpastatin and calpain play important roles in meat tenderization. However, it is not clear how phosphorylation affects the regulation of calpastatin on μ-calpain and, consequently, meat ...
Yuqiang Bai, Chengli Hou, Caiyan Huang, Fei Fang, Yu Dong, Xin Li, Dequan Zhang   +6 more
doaj   +1 more source

Expression of calpastatin gene in Raini Cashmere goat using Real Time PCR [PDF]

مجله بیوتکنولوژی کشاورزی, 2020
Objective Calpastatin has been found in skeletal muscle tissue of animals and could prevent unrestrained cellular growth by suppressing calpain activity. The involvement of calpains in apoptosis has been a subject of debate, although their involvement is
Mohammadreza Mohammadabadi
doaj   +1 more source

Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals. [PDF]

PLoS ONE, 2011
Calpain, a calcium-dependent cysteine protease, is reportedly involved in the pathophysiology of autoimmune diseases such as rheumatoid arthritis (RA).
Mikiko Iguchi-Hashimoto, Takashi Usui, Hajime Yoshifuji, Masakazu Shimizu, Shio Kobayashi, Yoshinaga Ito, Kosaku Murakami, Aoi Shiomi, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori   +13 more
doaj   +1 more source