Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis. [PDF]
PLoS ONE, 2015 Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic lymphocytic and acute myeloid leukemias the reduced apoptosis is strongly related with the activity ...
Anna Mikosik +7 more
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Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]
, 2001 Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Gross, Stefan +9 more
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Media Peternakan, 2013 Thin tail sheep has good adaptation in tropics condition, but they have low meat quality. Quality of thin tail hogget can be improved by selection. Calpastatin (CAST) gene is an indigenous inhibitor of calpain that involved in regulation of protein turn ...
B. W. Putra, C. Sumantri, Nurhidayat
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Frontiers in Genetics, 2018 Autogenous proteolytic enzymes of the calpain family are implicated in myofibrillar protein degradation. As a result, the μ-calpain gene and its specific inhibitor, calpastatin, have been repeatedly investigated for their association with meat quality ...
Joel D. Leal-Gutiérrez +5 more
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Journal of Experimental Neuroscience, 2017 Excessive intracellular calcium levels induce calpain activation, thereby triggering the cell death cascade. Several lines of evidence have demonstrated the neuroprotective role of the overexpression of calpain inhibitor, calpastatin.
Jirapa Chetsawang +4 more
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ANALYSIS OF POLYMORPHISM OF CAST GENE AND CLPG GENE IN SHEEP BY PCR-RFLP METHOD
Scientific Papers Animal Science and Biotechnologies, 2023 The work was oriented to identification of calpastatin gene polymorphism and callipyge gene polymorphism and analysis of genotype structure in population of sheep kept in Slovakia.
M. GÁBOR +2 more
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The role of proteinase enzymes in the process of conversion of muscle to meat [PDF]
Veterinarski Glasnik, 2006 Post mortem meat tenderization is a complex mechanism and unfortunately it has not been fully identified scientifically. It is known that endogenous proteinases have an important role in this mechanism.
Dümen Emek
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Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla
BMC Cancer, 2012 Background Pancreatic cancer, including cancer of the ampulla of Vater and bile duct, is very aggressive and has a poor five year survival rate; improved methods of patient stratification are required.
Storr Sarah J +6 more
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The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma. [PDF]
PLoS ONE, 2013 Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited by calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of the ...
Quentin Raimbourg +7 more
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The effect of calpastatin gene on meat quality traits in Turkish sheep breeds [PDF]
Iraqi Journal of Veterinary SciencesThis research aimed to examine the effects of haplotype groups observed in three different loci on the Calpastatin gene on ultrasonographic MLD measurements and seasonal live weight in five different types of sheep (GBK, HM, K, KM, and R).
Vasfiye K. Esen
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