Targeting NLRP3 Inflammasomes in Myocarditis: Potential Therapeutic Strategies and Clinical Translation. [PDF]
Scientifica (Cairo)Myocarditis can be caused by viral infections, systematic autoimmune diseases, and as a reaction to prescribed medications, and the nucleotide‐binding domain leucine‐rich repeat pyrin domain‐containing 3 (NLRP3) inflammasome is implicated in its pathophysiology.
Retnowati FD +3 more
europepmc +2 more sources
META-Analysis of the Relationship Between c.282C>G Polymorphism of the CAST Gene and Meat Quality Traits of Cattle. [PDF]
Vet Med SciThis meta‐analysis confirms a significant association between the c.282C>G polymorphism of the CAST gene and meat quality traits in cattle, highlighting the potential of the C allele and GC genotype in genetic selection for improved tenderness and meat characteristics.
Dincel D, Uzabaci E.
europepmc +2 more sources
Different nutritional systems influence the tenderness and lipid oxidation of ewe lamb meat without altering gene expression [PDF]
Anais da Academia Brasileira de Ciências, 2023 Feeding is a determining factor in the various characteristics of sheep meat and animal performance, the objectives were to evaluate the effect of supplementation of ewe lambs finished in different nutritional planes on the gene expression of CASP3 ...
ISABELLA G. SILVA +8 more
doaj +1 more source
Feeding strategies and ageing time alter calpain system proteins activities and meat quality of Braford steers [PDF]
Animal Bioscience, 2022 Objective The aim of this study was to evaluate the effect of ageing and feeding strategies on the calpain protease system and meat quality traits in Braford steers.
María Sumampa Coria +3 more
doaj +1 more source
The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy
Frontiers in Cardiovascular Medicine, 2021 L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cavα1 pore-forming subunit and the accessory subunits Cavβ, Cavα2δ, and Cavγ. Cavβ is a cytosolic protein that regulates channel
Simone Pickel +17 more
doaj +1 more source
Comprehensive behavioral phenotyping of calpastatin-knockout mice
Molecular Brain, 2008 Background Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways.
Nakajima Ryuichi +6 more
doaj +1 more source
Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
Cells, 2021 Ischemia/reperfusion (I/R) injury unavoidably occurs during hepatic resection and transplantation. Aged livers poorly tolerate I/R during surgical treatment.
Joseph Flores-Toro +9 more
doaj +1 more source
Is the expression of [-G93A(+)] human SOD1 a model to study neurodegenerations?
Journal of Biological Research, 2011 To relate the alterations occurring in neurodegenerations with Ca2+ homeostasis dysregulation, we analyzed the functional properties of the Ca2+-dependent calpain/calpastatin system in neuronal cells of transgenic mice overexpressing human mutated -G93A(+
R. Stifanese +6 more
doaj +1 more source
Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis. [PDF]
PLoS ONE, 2015 Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic lymphocytic and acute myeloid leukemias the reduced apoptosis is strongly related with the activity ...
Anna Mikosik +7 more
doaj +1 more source
Calpastatin Subdomains A and C Are Activators of Calpain [PDF]
Journal of Biological Chemistry, 2002 The inhibitory domains of calpastatin contain three highly conserved regions, A, B, and C, of which A and C bind calpain in a strictly Ca(2+)-dependent manner but have no inhibitory activity whereas region B inhibits calpain on its own. We synthesized the 19-mer oligopeptides corresponding to regions A and C of human calpastatin domain I and tested ...
Tompa, P +3 more
openaire +3 more sources