Comprehensive behavioral phenotyping of calpastatin-knockout mice [PDF]
Molecular Brain, 2008 Background Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways.
Nakajima Ryuichi +6 more
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Differential regulation of the calpain–calpastatin complex by the L-domain of calpastatin [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014 Here we demonstrate that the presence of the L-domain in calpastatins induces biphasic interaction with calpain. Competition experiments revealed that the L-domain is involved in positioning the first inhibitory unit in close and correct proximity to the calpain active site cleft, both in the closed and in the open conformation.
DE TULLIO, ROBERTA +6 more
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Calpain‐calpastatin and fusion [PDF]
FEBS Letters, 1986 Rat erythrocytes fuse when treated with the membrane mobility agent, 2‐(2‐methoxyethoxy)ethyl‐cis‐8‐(2‐octylcyclopropyl) octanoate (A2C) and Ca2+, whereas human cells do not. Membrane proteolysis promoted by calpain is required for rat cell fusion [(1986) Eur. J. Biochem., in press].
Glaser, Tova, Kosower, Nechama S.
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Properties of calpastatin forms in rat brain [PDF]
FEBS Letters, 1998 Four recombinant calpastatin forms, deduced from rat brain mRNAs and differing in the number of inhibitory repetitive domains from zero to four, were expressed and characterized for their inhibitory efficiency on μ‐ and m‐calpain. Although the most effective one is a truncated calpastatin form composed of the N‐terminal region (domain L) and a single ...
MELLONI, EDON +6 more
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Different nutritional systems influence the tenderness and lipid oxidation of ewe lamb meat without altering gene expression [PDF]
Anais da Academia Brasileira de Ciências, 2023 Feeding is a determining factor in the various characteristics of sheep meat and animal performance, the objectives were to evaluate the effect of supplementation of ewe lambs finished in different nutritional planes on the gene expression of CASP3 ...
ISABELLA G. SILVA +8 more
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Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals. [PDF]
PLoS ONE, 2011 Calpain, a calcium-dependent cysteine protease, is reportedly involved in the pathophysiology of autoimmune diseases such as rheumatoid arthritis (RA).
Mikiko Iguchi-Hashimoto +13 more
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Feeding strategies and ageing time alter calpain system proteins activities and meat quality of Braford steers [PDF]
Animal Bioscience, 2022 Objective The aim of this study was to evaluate the effect of ageing and feeding strategies on the calpain protease system and meat quality traits in Braford steers.
María Sumampa Coria +3 more
doaj +1 more source
The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy
Frontiers in Cardiovascular Medicine, 2021 L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cavα1 pore-forming subunit and the accessory subunits Cavβ, Cavα2δ, and Cavγ. Cavβ is a cytosolic protein that regulates channel
Simone Pickel +17 more
doaj +1 more source
Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
Cells, 2021 Ischemia/reperfusion (I/R) injury unavoidably occurs during hepatic resection and transplantation. Aged livers poorly tolerate I/R during surgical treatment.
Joseph Flores-Toro +9 more
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Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin [PDF]
, 2003 Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY.
Dominga Deluca +25 more
core +1 more source