Results 51 to 60 of about 4,652 (211)

Identification of Calpain Substrates by ORF Phage Display

Molecules, 2011
Substrate identification is the key to defining molecular pathways or cellular processes regulated by proteases. Although phage display with random peptide libraries has been used to analyze substrate specificity of proteases, it is difficult to deduce ...
Wei Li, Gabriela Alvarado, Nora B. Caberoy   +2 more
doaj   +1 more source

Connecting Heat Tolerance and Tenderness in Bos indicus Influenced Cattle

Animals, 2022
Bos indicus cattle are widely utilized in tropical and subtropical climates. Their heat tolerance and parasite resistance are integral for beef production in these regions; however, a reputation for excitable temperaments, slower growth, and variation in
Tracy L. Scheffler
doaj   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

Epidermolysis Bullosa Classification and Current Approach to Diagnosis

Pediatric Dermatology, Volume 43, Issue S2, Page 5-15, August 2026.
ABSTRACT Epidermolysis bullosa (EB) is a heterogeneous group of rare genodermatoses marked by skin fragility and bullae formation induced by minor trauma. Pathologic variants in at least 21 genes are associated with EB, grouped into four major subtypes based predominantly on the plane of cleavage within the skin.
Hannah E. Mumber, Marissa J. Perman
wiley   +1 more source

Calpastatin in erythrocytes of young and old individuals [PDF]

Biochemical Journal, 1994
To gain knowledge about the behaviour of calpastatin (the specific inhibitor of the Ca(2+)-dependent thiol protease calpain) in the intact cell, we analysed the inhibitor by specific antibodies and determined its activity in erythrocytes from individuals 20-34 years old (young) and 70-93 years old (old).
N, Schwarz-Benmeir, T, Glaser, S, Barnoy, N S, Kosower   +3 more
openaire   +2 more sources

Calpain‐4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol‐Related Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Calpain‐4 knockdown in alcohol‐related liver disease promotes LXRα nuclear translocation and HMGCR cleavage, enhancing cholesterol efflux via upregulation of ABCA1/ABCG1 and CPT‐1. This mechanism reduces hepatic cholesterol accumulation and microvesicular steatosis without affecting triglycerides or inflammatory markers, identifying calpain‐4 as a ...
Noriko Kitano, Jiang Li, Sam Taborski, Charis‐Marie Vanderpuye, Pooja Muddasani, Sudrishti Chaudhary, Jia‐Jun Liu, Silvia Liu, Juliane I. Beier, Josepmaria Argemi, Ramon Bataller, Gavin E. Arteel   +11 more
wiley   +1 more source

Assay of total calpastatin activity.

, 2012
The bar graph represents calpastatin activity in the sample groups. Calpastatin activity is shown as units of activity per 106 erythroid precursor cells.
Tipparat Penglong (164413), Saovaros Svasti (164396), Suriyan Sukati (164392), Nantika Panutdaporn (164408), Gerd Katzenmeier (164430), Monica Averna (164404), Edon Melloni (164418), Roberto Stifanese (164401), Suthat Fucharoen (164423)   +8 more
core   +1 more source

Ryanodine Receptor Ca2+ Leak‐Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The dystrophic mdx mouse is a widely used model of Duchenne muscular dystrophy. Altered Ca2+ handling is a key feature, including increased Ca2+ leak through the ryanodine receptor (RyR1's), the primary Ca2+ release channel in skeletal muscle. Such leak has important downstream consequences for intracellular Ca2+ homeostasis.
Rhayanna B. Gaglianone, Cedric R. Lamboley, Taylor Dick, Aldo Meizoso‐Huesca, Daniel P. Singh, Bradley S. Launikonis   +5 more
wiley   +1 more source

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

The structure of calpain and calpastatin.

, 2012
(A)The calpain-1 DI-DVI (green) with calpain-4 DVI (cyan) with a calpastatin subdomains A,B, and C (magenta). Dashed lines are where there was no density in the crystal structure for calpastatin.
Richard Bonneau (4318), P. Douglas Renfrew (177867), Brian Kuhlman (43313), Eun Jung Choi (177875)   +3 more
core   +1 more source