Results 51 to 60 of about 4,120 (216)
Calpastatin in erythrocytes of young and old individuals [PDF]
Biochemical Journal, 1994 To gain knowledge about the behaviour of calpastatin (the specific inhibitor of the Ca(2+)-dependent thiol protease calpain) in the intact cell, we analysed the inhibitor by specific antibodies and determined its activity in erythrocytes from individuals 20-34 years old (young) and 70-93 years old (old).
N, Schwarz-Benmeir +3 more
openaire +2 more sources
Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.Calpain‐4 knockdown in alcohol‐related liver disease promotes LXRα nuclear translocation and HMGCR cleavage, enhancing cholesterol efflux via upregulation of ABCA1/ABCG1 and CPT‐1. This mechanism reduces hepatic cholesterol accumulation and microvesicular steatosis without affecting triglycerides or inflammatory markers, identifying calpain‐4 as a ...
Noriko Kitano +11 more
wiley +1 more source
Polymorphism of Genes and Their Impact on Beef Quality
Current Issues in Molecular Biology, 2023 The single-nucleotide polymorphism (SNP) form of genes is a valuable source of information regarding their suitability for use as specific markers of desirable traits in beef cattle breeding.
Piotr Kostusiak +4 more
doaj +1 more source
Ryanodine Receptor Ca2+ Leak‐Induced Redistribution of Ca2+ in Dystrophic mdx Mouse Muscle
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim The dystrophic mdx mouse is a widely used model of Duchenne muscular dystrophy. Altered Ca2+ handling is a key feature, including increased Ca2+ leak through the ryanodine receptor (RyR1's), the primary Ca2+ release channel in skeletal muscle. Such leak has important downstream consequences for intracellular Ca2+ homeostasis.
Rhayanna B. Gaglianone +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva +4 more
wiley +1 more source
Identification of Calpain Substrates by ORF Phage Display
Molecules, 2011 Substrate identification is the key to defining molecular pathways or cellular processes regulated by proteases. Although phage display with random peptide libraries has been used to analyze substrate specificity of proteases, it is difficult to deduce ...
Wei Li +2 more
doaj +1 more source
Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells [PDF]
International Journal of Ophthalmology, 2019 AIM: To detect how BRCA-associated protein 1 (BAP1) regulates cell migration in uveal melanoma (UM) cells. METHODS: Wound healing and transwell assays were performed to detect UM cell migration abilities.
Han Yue +5 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.This graphical abstract summarizes the comprehensive framework of mutton quality, including evaluation indices, influencing factors, and improvement strategies. Meat quality is systematically assessed through multiple dimensions, including flavor, color, pH, tenderness, water‐holding capacity, intramuscular fat, and nutritional composition.
Man‐yu Liu +6 more
wiley +1 more source
Study on genetic structure of CAST gene by PCR- SSCP method and its association with growth traits in lori-Bakhtiari sheep breed [PDF]
مجله بیوتکنولوژی کشاورزی, 2014 In this study, a 254 bp fragment containing exon 6 and a part of introns 5 and 6 of ovine CAST gene were amplified in 169 Lori-Bakhtiari lamb from Lori-Bakhtiari sheep breeding station by polymerase chain reactions.
Mohsen Ali +3 more
doaj +1 more source
Assay of total calpastatin activity.
, 2012 The bar graph represents calpastatin activity in the sample groups. Calpastatin activity is shown as units of activity per 106 erythroid precursor cells.
Tipparat Penglong (164413) +8 more
core +1 more source