Results 71 to 80 of about 4,652 (211)

Effect of Ca2+ on binding of the calpains to calpastatin

Journal of Biological Chemistry, 1989
Autolyzed mu-calpain, unautolyzed mu-calpain, autolyzed m-calpain, and unautolyzed m-calpain (mu-calpain is the micromolar Ca2+-requiring proteinase, m-calpain is the millimolar Ca2+-requiring proteinase) were passed through a calpastatin-affinity column at different free Ca2+ concentrations, and binding of the calpains to calpastatin was compared with
H P, Kapprell, D E, Goll
openaire   +2 more sources

Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold

Advanced Science, Volume 12, Issue 48, December 29, 2025.
In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu, Zhengxin Li, Zhuoqi Zheng, Bo Zhang, Bozitao Zhong, Jie Bai, Xiaokun Hong, Taifeng Wang, Ting Wei, Jianyi Yang, Hai‐Feng Chen   +10 more
wiley   +1 more source

Tenderness and the Calpain System of Three Different Types of Muscles of Kejobong Does under Two Different Energy Levels

Animal Production: Indonesian Journal of Animal Production, 2012
. The purpose of research was to investigate whether there was influence of the addition of concentrates in basal feed on meat tenderness and calpastatin and calpain activities of three muscles of Kejobong does.
M Socheh, Ismaya Ismaya, I Gede Suparta Budisatria, Kustantinah Kustantinah   +3 more
doaj  

Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis and Knuckle Pads (PLACK) Syndrome: An Updated Review of Cases and Identification of a Recurrent CAST Variant in Two Patients

Pediatric Dermatology, Volume 42, Issue 6, Page 1239-1247, November/December 2025.
ABSTRACT Peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK) syndrome (OMIM616295) is an exceptionally rare autosomal recessive genodermatosis caused by loss‐of‐function pathogenic variants in the CAST gene, encoding calpastatin.
Fiona Haxho, Richard M. Haber, Janan Mohamad, Ofer Sarig, Eli Sprecher, Renée Perrier, Dana Boctor, Michele Ramien   +7 more
wiley   +1 more source

Association of single nucleotide polymorphisms in CAPN1 and CAST genes with beef tenderness from Spanish commercial feedlots

Czech Journal of Animal Science, 2013
Frequencies of two SNPs in the μ-calpain (CAPN1) and calpastatin (CAST) genes in local and foreign commercial cross-breeds used in south-western Spain (Charolais, Limousin, and Retinta) were evaluated and the association of these markers with texture ...
C. Avilés, M. Juárez, F. Peña, V. Domenech, I. Clemente, A. Molina   +5 more
doaj   +1 more source

Adipocyte Calpain‐2 Deficiency Reduces Obesity‐Accelerated Abdominal Aortic Aneurysm Formation in Mice

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Adipocyte‐specific deletion of calpain‐2 in mice decreases obesity‐accelerated abdominal aortic aneurysm formation, which is associated with reduced aortic medial elastin fragmentation and periaortic adipose tissue leukocyte accumulation. Targeted inhibition of calpain‐2 may offer a new therapeutic target to reduce obesity‐accelerated abdominal aortic ...
Ana Clara Frony, Aida Javidan, Weihua Jiang, Michihiro Okuyama, Lihua Yang, Haruhito A. Uchida, Venkateswaran Subramanian   +6 more
wiley   +1 more source

A new rat model for studying the calpain-calpastatin system

, 1995
A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a
S. Salardi, G. Bianchi, L. Soldati, B. R. Barber, I. Molinari   +4 more
core   +1 more source

Validation Study of SNPs in CAPN1-CAST Genes on the Tenderness of Muscles (Longissimus thoracis and Semimembranosus) in Hanwoo (Korean Cattle)

Animals, 2019
Previous studies demonstrated that polymorphisms in the μ-calpain (CAPN1) and calpastatin (CAST) genes had significant effects on meat tenderness in different cattle populations.
Hyo Jun Lee, Shil Jin, Hyoun-Joo Kim, Mohammad Shamsul Alam Bhuiyan, Doo Ho Lee, Soo Hyun Lee, Sung Bong Jang, Man Hye Han, Seung Hwan Lee   +8 more
doaj   +1 more source

Calpains and Calpastatin in Human Blood Platelets

Platelets, 1995
Calpain, a Ca(2+) activated intracellular protease and its endogeneous protein inhibitor, calpastatin are abundant in platelets. The structure and enzymological properties of calpain, including its isozymes, and of calpastatin in platelets have been fully characterized.
H, Ariyoshi, J, Kambayashi, M, Sakon
openaire   +2 more sources

Dry‐Aged Beef: A Global Review of Meat Quality Traits, Microbiome Dynamics, Safety, and Sustainable Strategies

Journal of Food Science, Volume 90, Issue 10, October 2025.
ABSTRACT Dry‐aged beef is valued for its tenderness, complex aroma, and concentrated flavor. However, variability in aging protocols and limited understanding of underlying biological and technological processes can compromise consistent quality and safety.
Ana J. Ribeiro, Filipe Silva, Paula Teixeira, Cristina M. Saraiva   +3 more
wiley   +1 more source