Results 71 to 80 of about 4,120 (216)

Association of Calpastatin with Inactive Calpain [PDF]

Journal of Biological Chemistry, 2006
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Melloni, Edon, Averna, Monica, Stifanese, Roberto, De Tullio, Roberta, Defranchi, Enrico, Salamino, Franca, Pontremoli, Sandro   +6 more
openaire   +2 more sources

Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy‐Supportive Phenotype In Vitro

European Journal of Immunology, Volume 55, Issue 9, September 2025.
Fecal extracellular vesicles (fEVs) were isolated from preserved stool samples in DNA/RNA shield and characterized. In an in vitro model with PBMC, fEVs of pregnant women modulate T cells toward a regulatory phenotype favorable for pregnancy compared to fEVs of non‐pregnant women. ABSTRACT Pregnancy requires immune tolerance to a semi‐allogeneic fetus,
Stefanie Dietz‐Ziegler, Samantha Kewitz, Gabriele Kaiser, Jessica Rühle, Alexander Marmé, Alexander Dalpke, Bachar Cheaib, Jan Pauluschke‐Fröhlich, Melanie Henes, Ana Velic, Andreas Pich, Anneli Vollert, Martin Schaller, Felix Knab, Trim Lajqi, Christian F. Poets, Christian Gille, Natascha Köstlin‐Gille   +17 more
wiley   +1 more source

Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin. [PDF]

PLoS ONE, 2017
Calpains are calcium-activated proteases that have biomedical and biotechnological potential. Their activity is tightly regulated by their endogenous inhibitor, calpastatin that binds to the enzyme only in the presence of calcium. Conventional approaches
Hung Huy Nguyen, Mihaly Varadi, Peter Tompa, Kris Pauwels   +3 more
doaj   +1 more source

Analysis of Population Structure and Selection Signatures in Two Iraqi Fat‐Tailed Sheep Breeds

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Awassi sheep exhibit clear genetic separation, whereas Hamdani sheep show an admixed profile, with iHS, ROH and Tajima's D analyses identifying breed‐specific candidate genes. Enrichment in immune response, hormone regulation and cellular signalling pathways highlights adaptive evolution and guides future breeding and conservation.
Mervan Bayraktar, Omer Shoshin, K. A. Saravanan, Tahreer M. Al‐Thuwaini, Gökhan Gökçe, Zeynab Hussein Fadhil, Melis Çelik Güney   +6 more
wiley   +1 more source

Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity

British Journal of Pharmacology, Volume 182, Issue 17, Page 4103-4121, September 2025.
Abstract Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contraction coupling.
Wesam Bassiouni, Brandon Y. H. Chan, Andrej Roczkowsky, Joshua W. Kranrod, Zabed Mahmud, Joseph O. Primeau, Woo Jung Cho, Howard S. Young, John M. Seubert, Richard Schulz   +9 more
wiley   +1 more source

A new rat model for studying the calpain-calpastatin system

, 1995
A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a
S. Salardi, G. Bianchi, L. Soldati, B. R. Barber, I. Molinari   +4 more
core   +1 more source

Tenderness and the Calpain System of Three Different Types of Muscles of Kejobong Does under Two Different Energy Levels

Animal Production: Indonesian Journal of Animal Production, 2012
. The purpose of research was to investigate whether there was influence of the addition of concentrates in basal feed on meat tenderness and calpastatin and calpain activities of three muscles of Kejobong does.
M Socheh, Ismaya Ismaya, I Gede Suparta Budisatria, Kustantinah Kustantinah   +3 more
doaj  

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Quantification of calpastatin using an optical surface plasmon resonance biosensor

, 2011
An immunological biosensor for calpastatin was developed on a surface plasmon resonance based system (Biacore Q). The performance of the biosensor assay was evaluated using ovine and bovine muscle and heart extracts with known calpastatin activity.
van der Palen, JGP, Hemke, G, Geesink, Geert, Koohmaraie, M, Kent, MP, Veiseth, E   +5 more
core   +1 more source

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.

Frontiers in Cellular Neuroscience, 2013
Excitotoxicity is a major component of neurodegenerative diseases and is typically accompanied by an inflammatory response. Cytokines IL-1alpha and IL-1beta are key regulators of this inflammatory response and modulate the activity of numerous cell types,
David eGosselin, Marc-Andre eBellavance, Serge eRivest   +2 more
doaj   +1 more source