Results 81 to 90 of about 4,120 (216)
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, Volume 12, Issue 25, July 3, 2025.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
Immunity and neuroinflammation in early stages of life and epilepsy
Epilepsia, Volume 66, Issue 7, Page 2157-2169, July 2025.Abstract The immune system is crucial for the correct brain development, and recent findings also point toward central control of immune response. As the immune system is not fully developed at birth, the early years become an important window for infections and for the development of epilepsy.
Angelica Vega García +5 more
wiley +1 more source
Calpains and Calpastatin in Human Blood Platelets
Platelets, 1995 Calpain, a Ca(2+) activated intracellular protease and its endogeneous protein inhibitor, calpastatin are abundant in platelets. The structure and enzymological properties of calpain, including its isozymes, and of calpastatin in platelets have been fully characterized.
H, Ariyoshi, J, Kambayashi, M, Sakon
openaire +2 more sources
Molecular Oncology, Volume 19, Issue 6, Page 1855-1875, June 2025.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Identification of active calpastatin molecular species.
, 2012 A) Activity profiles of samples from 106 erythroid precursor cells isolated from control and patients with mild and severe clinical symptoms, respectively. Numbers at the bottom refer to the molecular weight of proteins present in the gel slices.
Tipparat Penglong (164413) +8 more
core +1 more source
Differential tissue expression of a calpastatin isoform in Xenopus embryos
, 2007 This study is aimed at demonstrating the role played by a calpastatin isoform (Xcalp3) in Xenopus embryos. A specific monoclonal antibody (mAb) was raised against a glutathione S-transferase (GST)-Xcalp3 fusion protein and characterized by immunoblotting
M. MAZZINI +7 more
core +2 more sources
ESC Heart Failure, Volume 12, Issue 3, Page 2256-2266, June 2025.Abstract Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. We now address the question of whether inhibition of calpain function in cardiomyocytes, and thereby ...
Gregor Sachse +9 more
wiley +1 more source
Abstract 4755: Calpastatin phosphorylation regulates radiation response in glioblastoma
, 2017 Glioblastoma (GBM) is the most prevalent and aggressive primary malignant brain tumor in adults. Patients diagnosed with GBM have a very poor prognosis and quality of life, with a median survival time of 12-15 months despite receiving the standard of ...
Mitchell Pearson +4 more
core +1 more source
Differences in skeletal muscle proteolysis in Nellore and Angus cattle might be driven by Calpastatin activity and not the abundance of Calpain/Calpastatin [PDF]
, 2017 The present study aimed to explore the molecular factors underlying differences in Calpain/Calpastatin proteolytic system in Nellore and Angus cattle.
Duarte, M. S. +15 more
core +1 more source
Rosetta predictions for experimentally tested calpain/calpastatin interface redesigns.
, 2012 Calpain is shown in cyan and calpastatin is shown in magenta, with the calpastatin position shown in yellow. Rosetta predictions for calpastatin position 607, wild type serine (A), amino-butyeiric acid (B), norvaline (C).
Richard Bonneau (4318) +3 more
core +1 more source