Results 11 to 20 of about 49,188 (286)
An eccentric calpain, CAPN3/p94/calpain-3
Biochimie, 2016 Calpains are Ca(2+)-regulated proteolytic enzymes that are involved in a variety of biological phenomena. Calpains process substrates by limited proteolysis to modulate various protein functions in the cell, and are thus called "modulator proteases." CAPN3, previously called p94 or calpain-3, has unique features that are not found in any of the other ...
Ono, Yasuko +4 more
openaire +3 more sources
Calpains in Cyanobacteria and the Origin of Calpains [PDF]
Scientific Reports, 2022 Abstract Calpains are cysteine proteases involved in many cellular processes. They are an ancient and large superfamily of enzymes responsible for the cleavage and irreversible modification of a large variety of substrates. They have been intensively studied in humans and other mammals, but information about calpains in bacteria is scarce ...
Dominika Vešelényiová +5 more
openaire +4 more sources
Biochemical and Biophysical Research Communications, 1989 The calpain-induced proteolysis of tau associated with twice-cycled microtubules or from a total brain heat-stable fraction was studied. Twice-cycled microtubule tau was rapidly hydrolyzed by calpain.
Johnson, Gail V.W +2 more
core +3 more sources
Basic Research in Cardiology, 2022 Treatment options for myocarditis are currently limited. Inhibition of calpains has been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the underlying mechanism of action of calpains has not been elucidated.
Xiaoxiao Liu +8 more
semanticscholar +1 more source
Calpain as a therapeutic target in cancer
Expert opinion on therapeutic targets, 2022 Introduction Calpain-1 and calpain-2 are prototypical classical isoforms of the calpain family of calcium-activated cysteine proteases. Their substrate proteins participate in a wide range of cellular processes, including transcription, survival ...
I. Shapovalov, Danielle Harper, P. Greer
semanticscholar +1 more source
Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease
Cells, 2021 Calpains belong to the family of calcium-dependent cysteine proteases expressed ubiquitously in mammals and many other organisms. Activation of calpain is observed in diseased hearts and is implicated in cardiac cell death, hypertrophy, fibrosis, and ...
Mengxiao Zhang, Grace Wang, T. Peng
semanticscholar +1 more source
Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. [PDF]
PLoS ONE, 2011 Calpain proteases drive intracellular signal transduction via specific proteolysis of multiple substrates upon Ca(2+)-induced activation. Recently, dUTPase, an enzyme essential to maintain genomic integrity, was identified as a physiological calpain ...
Zoltán Bozóky +6 more
doaj +1 more source
Cell Research, 2020 A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic.
Chunlong Ma +10 more
semanticscholar +1 more source
Biomolecules, 2023 Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP ...
Yujie Dong +6 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear.
L. Qiu +7 more
semanticscholar +1 more source