Results 11 to 20 of about 27,479 (162)

Calpain: the regulatory point of myocardial ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine, 2023
Calpain is a conserved cysteine protease readily expressed in several mammalian tissues, which is usually activated by Ca2+ and with maximum activity at neutral pH.
Guo-Yang Liu, Guo-Yang Liu, Guo-Yang Liu, Wan-Li Xie, Wan-Li Xie, Wan-Li Xie, Yan-Ting Wang, Yan-Ting Wang, Yan-Ting Wang, Lu Chen, Lu Chen, Lu Chen, Zhen-Zhen Xu, Zhen-Zhen Xu, Zhen-Zhen Xu, Yong Lv, Yong Lv, Yong Lv, Qing-Ping Wu, Qing-Ping Wu, Qing-Ping Wu   +20 more
doaj   +1 more source

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Scientific Reports, 2022
Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for excitation ...
Gunnar Weninger, Tatiana Pochechueva, Dana El Chami, Xiaojing Luo, Tobias Kohl, Sören Brandenburg, Henning Urlaub, Kaomei Guan, Christof Lenz, Stephan E. Lehnart   +9 more
doaj   +1 more source

GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. [PDF]

PLoS ONE, 2011
As one of the most essential post-translational modifications (PTMs) of proteins, proteolysis, especially calpain-mediated cleavage, plays an important role in many biological processes, including cell death/apoptosis, cytoskeletal remodeling, and the ...
Zexian Liu, Jun Cao, Xinjiao Gao, Qian Ma, Jian Ren, Yu Xue   +5 more
doaj   +1 more source

Novel insights into the progression and prognosis of the calpain family members in hepatocellular carcinoma: a comprehensive integrated analysis

Frontiers in Molecular Biosciences, 2023
Objectives: The goal of our bioinformatics study was to comprehensively analyze the association between the whole calpain family members and the progression and prognosis of hepatocellular carcinoma (HCC).Methods: The data were collected from The Cancer ...
Dongjun Dai, Dongjun Dai, Dehao Wu, Runliang Ni, Runliang Ni, Ping Li, Ping Li, Zhifeng Tian, Zhifeng Tian, Yongjie Shui, Hanguang Hu, Hanguang Hu, Qichun Wei, Qichun Wei   +13 more
doaj   +1 more source

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Cell Discovery, 2023
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of ...
Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello   +9 more
doaj   +1 more source

Activation of calpain-1 in human carotid artery atherosclerotic lesions

BMC Cardiovascular Disorders, 2009
Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and ...
Pedro Luis M, Dias Nuno, Saido Takaomi C, Nitulescu Mihaela, Gonçalves Isabel, e Fernandes José, Ares Mikko PS, Pörn-Ares Isabella   +7 more
doaj   +1 more source

Calpain Activity Is Generally Elevated during Transformation but Has Oncogene-Specific Biological Functions

Neoplasia: An International Journal for Oncology Research, 2004
Several oncogene and tumor-suppressor gene products are known substrates for the calpain family of cysteine proteases, and calpain is required for transformation by v-src and tumor invasion.
N.O. Carragher, B.D. Fonseca, M.C. Frame
doaj   +1 more source

Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]

PLoS ONE, 2015
Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu, Wei Liu, Yu Deng, Tian-Yao Yang, Shu Feng, Zhao-Fa Xu   +5 more
doaj   +1 more source

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. [PDF]

PLoS Genetics, 2010
Calpains constitute a superfamily of Ca2+-dependent cysteine proteases, indispensable for various cellular processes. Among the 15 mammalian calpains, calpain 8/nCL-2 and calpain 9/nCL-4 are predominantly expressed in the gastrointestinal tract and are ...
Shoji Hata, Manabu Abe, Hidenori Suzuki, Fujiko Kitamura, Noriko Toyama-Sorimachi, Keiko Abe, Kenji Sakimura, Hiroyuki Sorimachi   +7 more
doaj   +1 more source

The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells

Skeletal Muscle, 2020
Background Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging.
Clayton Whitmore, Evan P.S. Pratt, Luke Anderson, Kevin Bradley, Sawyer M. Latour, Mariam N. Hashmi, Albert K. Urazaev, Rod Weilbaecher, Judith K. Davie, Wen-Horng Wang, Gregory H. Hockerman, Amber L. Pond   +11 more
doaj   +1 more source