Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis [PDF]
CellsIn breast cancer, progression from localized stage I to distant metastatic stage IV disease is associated with a reduction of 5-year survival from nearly 100% to 23.2%.
Danielle Harper +7 more
doaj +4 more sources
Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death [PDF]
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
doaj +3 more sources
Role of Calpain-1 in Neurogenesis [PDF]
Frontiers in Molecular Biosciences, 2021 While calpains have been implicated in neurogenesis for a long time, there is still little information regarding the specific contributions of various isoforms in this process.
Michel Baudry +4 more
doaj +2 more sources
Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade [PDF]
BMC Complementary Medicine and Therapies, 2021 Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding +5 more
doaj +2 more sources
Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes [PDF]
Frontiers in Cardiovascular MedicineObjectiveAstragaloside IV (AsIV) has been reported to alleviate diabetes-induced endothelial dysfunction by inhibiting calpain-1. This study aimed to determine whether the same mechanism underlies its protective effect against diabetic cardiomyopathy ...
Qinglong Zhang +5 more
doaj +2 more sources
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment [PDF]
OncoImmunologyTumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials.
Zuhairah Binte Hanafi +7 more
doaj +2 more sources
Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis [PDF]
Biochemistry and Biophysics Reports, 2021 Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial calpain-
Mayu Sugawara +4 more
doaj +2 more sources
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition [PDF]
Heliyon, 2023 Background: Previous studies have demonstrated the beneficial effect of baicalin on pulmonary arterial hypertension (PAH), but the mechanism is unclear.
He-xi Jiang +3 more
doaj +2 more sources
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway [PDF]
Neural Plasticity, 2022 Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases.
Yan Meng +8 more
doaj +2 more sources
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Xiaoning Bi +2 more
exaly +3 more sources