Role of Calpain-1 in Neurogenesis [PDF]
Frontiers in Molecular Biosciences, 2021 While calpains have been implicated in neurogenesis for a long time, there is still little information regarding the specific contributions of various isoforms in this process.
Michel Baudry +4 more
doaj +5 more sources
Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis [PDF]
CellsIn breast cancer, progression from localized stage I to distant metastatic stage IV disease is associated with a reduction of 5-year survival from nearly 100% to 23.2%.
Danielle Harper +7 more
doaj +4 more sources
Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade [PDF]
BMC Complementary Medicine and Therapies, 2021 Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding +5 more
doaj +2 more sources
Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes [PDF]
Frontiers in Cardiovascular MedicineObjectiveAstragaloside IV (AsIV) has been reported to alleviate diabetes-induced endothelial dysfunction by inhibiting calpain-1. This study aimed to determine whether the same mechanism underlies its protective effect against diabetic cardiomyopathy ...
Qinglong Zhang +5 more
doaj +2 more sources
Activation of calpain-1 in human carotid artery atherosclerotic lesions [PDF]
BMC Cardiovascular Disorders, 2009 Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and ...
Pedro Luis M +7 more
doaj +3 more sources
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment [PDF]
OncoImmunologyTumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials.
Zuhairah Binte Hanafi +7 more
doaj +2 more sources
Commentary on: Calpain-2 participates in the process of calpain-1 inactivation. [PDF]
Biosci Rep, 2021 Abstract Calpain belongs to the calcium-dependent non-lysosomal cysteine protease. Calpain-1 (C1) and calpain-2 (C2) expression are ubiquitous in mammals and an important mediator of the action of calcium. Specific substrate cleavage by C1 and C2 is critical for several calcium-dependent cellular pathways including neuronal function ...
Kumari R, Maiti TK.
europepmc +4 more sources
Calpain-2 participates in the process of calpain-1 inactivation. [PDF]
Biosci Rep, 2020 Abstract Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity.
Shinkai-Ouchi F +4 more
europepmc +4 more sources
Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis [PDF]
Biochemistry and Biophysics Reports, 2021 Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial calpain-
Mayu Sugawara +4 more
doaj +2 more sources
Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death [PDF]
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
doaj +2 more sources