Role of Calpain-1 in Neurogenesis [PDF]
Frontiers in Molecular Biosciences, 2021 While calpains have been implicated in neurogenesis for a long time, there is still little information regarding the specific contributions of various isoforms in this process.
Michel Baudry +4 more
doaj +5 more sources
Calpain-1 and Calpain-2 Promote Breast Cancer Metastasis [PDF]
CellsIn breast cancer, progression from localized stage I to distant metastatic stage IV disease is associated with a reduction of 5-year survival from nearly 100% to 23.2%.
Danielle Harper +7 more
doaj +4 more sources
Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade [PDF]
BMC Complementary Medicine and Therapies, 2021 Background Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates ...
Yin Ding +5 more
doaj +2 more sources
Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes [PDF]
Frontiers in Cardiovascular MedicineObjectiveAstragaloside IV (AsIV) has been reported to alleviate diabetes-induced endothelial dysfunction by inhibiting calpain-1. This study aimed to determine whether the same mechanism underlies its protective effect against diabetic cardiomyopathy ...
Qinglong Zhang +5 more
doaj +2 more sources
Activation of calpain-1 in human carotid artery atherosclerotic lesions [PDF]
BMC Cardiovascular Disorders, 2009 Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and ...
Pedro Luis M +7 more
doaj +3 more sources
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment [PDF]
OncoImmunologyTumor-promoting inflammation significantly impacts cancer progression, and targeting inflammatory cytokines has emerged as a promising therapeutic approach in clinical trials.
Zuhairah Binte Hanafi +7 more
doaj +2 more sources
Commentary on: Calpain-2 participates in the process of calpain-1 inactivation. [PDF]
Biosci Rep, 2021 Abstract Calpain belongs to the calcium-dependent non-lysosomal cysteine protease. Calpain-1 (C1) and calpain-2 (C2) expression are ubiquitous in mammals and an important mediator of the action of calcium. Specific substrate cleavage by C1 and C2 is critical for several calcium-dependent cellular pathways including neuronal function ...
Kumari R, Maiti TK.
europepmc +4 more sources
Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis [PDF]
Biochemistry and Biophysics Reports, 2021 Calpains are Ca2+-dependent cysteine proteases; their aberrant activation is associated with several neurodegenerative diseases. The μ-calpain catalytic subunit, calpain-1, is located in the cytoplasm as well as in the mitochondria. Mitochondrial calpain-
Mayu Sugawara +4 more
doaj +2 more sources
Calpain-2 participates in the process of calpain-1 inactivation. [PDF]
Biosci Rep, 2020 Abstract Calpain-1 and calpain-2 are highly structurally similar isoforms of calpain. The calpains, a family of intracellular cysteine proteases, cleave their substrates at specific sites, thus modifying their properties such as function or activity.
Shinkai-Ouchi F +4 more
europepmc +4 more sources
Formation of the calpain-1/calpastatin complex promotes activation of calpain-1 under oxidizing conditions. [PDF]
J Anim SciAbstract Calpains are cysteine proteinases responsible for many biological roles in muscle, including protein degradation, muscle growth, and myoblast fusion. Calpains are inhibited by calpastatin, an endogenous inhibitor. Other factors, such as variations in pH, ionic strength, and oxidation influence calpain activity.
Maddock Carlin KR +3 more
europepmc +4 more sources