Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease. [PDF]
PLoS ONE, 2015 Here we demonstrate that heat shock protein 90 (HSP90) interacts with calpain-1, but not with calpain-2, and forms a discrete complex in which the protease maintains its catalytic activity, although with a lower affinity for Ca2+.
Monica Averna +7 more
doaj +1 more source
Quantification and structure-function analysis of calpain-1 and calpain-2 protease subunit interactions. [PDF]
J Biol ChemCalpain-1 and calpain-2 are heterodimeric proteases consisting of a common small regulatory subunit CAPNS1 and a large catalytic subunit, CAPN1 or CAPN2, respectively.
Shapovalov I +13 more
europepmc +2 more sources
Proteomic investigation of the class IA phosphoinositide 3-kinase signalling pathway [PDF]
, 2012 PhDClass IA phosphoinositide 3-kinases (PI3Ks) are a family of enzymes with key roles in the regulation of signalling pathways, many of which are mediated through Akt.
Beltran, Luisa
core +4 more sources
Calpain-1 and Calpain-2 in the Brain: Dr. Jekill and Mr Hyde? [PDF]
Current Neuropharmacology, 2019 Michel Baudry
exaly +2 more sources
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. [PDF]
PLoS ONE, 2015 We have recently demonstrated that in resting conditions calpain 1, but not calpain 2, is specifically associated to the N-Methyl-D-Aspartate receptor (NMDAR) multiprotein complex.
Monica Averna +8 more
doaj +1 more source
Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo
Biochemistry and Biophysics Reports, 2021 Background: Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Methods: Here, we performed left anterior descending coronary artery ligation in rats as a model for ischemic systolic ...
Kun Zhang +13 more
doaj +1 more source
Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain [PDF]
, 2001 Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an ...
Gross, Stefan +9 more
core +1 more source
The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and-9 and invasion by leukemic THP-1 cells [PDF]
, 2003 The ubiquitous proteases μ- and m-calpain are Ca2+-dependent cysteine endopeptidases. Besides involvement in a variety of physio(patho)logical processes, recent studies suggest a pivotal role of calpains in differentiation of hematopoietic cells and ...
Ries, C. +5 more
core +1 more source
Frontiers in Oncology, 2022 The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor mediating the clearance of various molecules from the extracellular matrix.
Benoit Langlois +17 more
doaj +1 more source
Formation of the calpain-1/calpastatin complex promotes activation of calpain-1 under oxidizing conditions. [PDF]
J Anim SciCalpains are cysteine proteinases responsible for many biological roles in muscle, including protein degradation, muscle growth, and myoblast fusion. Calpains are inhibited by calpastatin, an endogenous inhibitor. Other factors, such as variations in pH,
Maddock Carlin KR +3 more
europepmc +2 more sources