Results 21 to 30 of about 21,266,386 (226)

Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration [PDF]

Trends in Neurosciences, 2016
Many signaling pathways participate in both synaptic plasticity and neuronal degeneration. While calpains participate in these phenomena, very few studies have evaluated the respective roles of the two major calpain isoforms in the brain, calpain-1 and calpain-2.
Michel Baudry, Xiaoning Bi
exaly   +3 more sources

Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway [PDF]

Journal of Ginseng Research
Background: Hypoxic pulmonary hypertension (HPH) is the main pathological change in vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some research results have shown that ginsenoside Rg1 (Rg1) can improve vascular remodeling, but
Chenyang Ran, Meili Lu, Fang Zhao, Yi Hao, Xinyu Guo, Yunhan Li, Yuhong Su, Hongxin Wang   +7 more
doaj   +2 more sources

Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition. [PDF]

PLoS ONE
Exposure to arsenic or sugary drinks can increase the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), although the mechanisms involved and its possible interactions remain unexplored.
Myrian Velasco, Rosa Isela Ortiz-Huidobro, Ana María Salazar, Marcia Hiriart, Patricia Ostrosky-Wegman, Pablo Pánico   +5 more
doaj   +2 more sources

Calpain 1 gene expression in liver tissue and the association of novel calpain 1 single-nucleotide polymorphisms (SNPs) with meat quality in Bali cattle. [PDF]

Arch Anim Breed
Abstract. Calpain 1 (CAPN1) is an enzyme that influences meat tenderization, and it is involved in post mortem proteolysis. The bovine CAPN1 gene was chosen as a candidate gene for DNA sequencing to identify novel single-nucleotide polymorphisms (SNPs) in exons 8–10 and assess their associations with meat quality in Bali cattle.
Dairoh, Ulum MF, Jakaria, Sumantri C.
europepmc   +4 more sources

Calpain-1 Cleaves Rad21 To Promote Sister Chromatid Separation [PDF]

Molecular and Cellular Biology, 2011
Defining the mechanisms of chromosomal cohesion and dissolution of the cohesin complex from chromatids is important for understanding the chromosomal missegregation seen in many tumor cells. Here we report the identification of a novel cohesin-resolving protease and describe its role in chromosomal segregation.
Anil K, Panigrahi, Nenggang, Zhang, Qilong, Mao, Debananda, Pati   +3 more
openaire   +3 more sources

Calpain-3 not only proteolyzes calpain-1 and -2 but also is a substrate for calpain-1 and -2

The Journal of Biochemistry, 2023
Abstract Calpain is an intracellular cysteine protease that cleaves its specific substrates in a limited region to modulate cellular function. Calpain-1 (C1) and calpain-2 (C2) are ubiquitously expressed in mammalian cells, but calpain-3 (C3) is a skeletal muscle-specific type.
Koichi Ojima, Shoji Hata, Fumiko Shinkai-Ouchi, Yasuko Ono, Susumu Muroya   +4 more
openaire   +2 more sources

Changes in neurodegeneration-related miRNAs in brains from CAPN1−/− mice

BBA Advances, 2021
Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs.
Wenyue Su, Xiaoning Bi, Yubin Wang, Michel Baudry   +3 more
doaj   +1 more source

Quantification and structure-function analysis of calpain-1 and calpain-2 protease subunit interactions. [PDF]

J Biol Chem
Calpain-1 and calpain-2 are heterodimeric proteases consisting of a common small regulatory subunit CAPNS1 and a large catalytic subunit, CAPN1 or CAPN2, respectively.
Shapovalov I, Rimal P, Poudel P, Lewtas V, Bell M, Panday SK, Laight BJ, Harper D, Grieve S, Baillie GS, Nouri K, Davies PL, Alexov E, Greer PA.   +13 more
europepmc   +2 more sources

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. [PDF]

PLoS ONE, 2008
Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial
Liqun Jiang, Mingyi Wang, Jing Zhang, Robert E Monticone, Richard Telljohann, Gaia Spinetti, Gianfranco Pintus, Edward G Lakatta   +7 more
doaj   +1 more source

Calpain-1 Cleaves and Activates Caspase-7 [PDF]

Journal of Biological Chemistry, 2009
Caspase-7 is an executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases. The mechanism of caspase-7 activation by granzyme B and caspase-3 has been well characterized. However, whether other proteases such as calpains activate or inactivate caspase-7 is not known.
Juliette, Gafni, Xin, Cong, Sylvia F, Chen, Bradford W, Gibson, Lisa M, Ellerby   +4 more
openaire   +2 more sources