Results 31 to 40 of about 26,728 (182)

Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Biochemistry and Biophysics Reports, 2021
Background: Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Methods: Here, we performed left anterior descending coronary artery ligation in rats as a model for ischemic systolic ...
Kun Zhang, Melissa M. Cremers, Stephan Wiedemann, David M. Poitz, Christian Pfluecke, Frank R. Heinzel, Burkert Pieske, Volker Adams, Antje Schauer, Robert Winzer, Ruth H. Strasser, Axel Linke, Silvio Quick, Felix M. Heidrich   +13 more
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LRP-1-dependent control of calpain expression and activity: A new mechanism regulating thyroid carcinoma cell adhesion

Frontiers in Oncology, 2022
The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor mediating the clearance of various molecules from the extracellular matrix.
Benoit Langlois, Benoit Langlois, Julie Martin, Julie Martin, Christophe Schneider, Christophe Schneider, Cathy Hachet, Cathy Hachet, Christine Terryn, Damien Rioult, Laurent Martiny, Laurent Martiny, Louis Théret, Louis Théret, Stéphanie Salesse, Stéphanie Salesse, Stéphane Dedieu, Stéphane Dedieu   +17 more
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Neuroprotection in Glaucoma Using Calpain-1 Inhibitors: Regional Differences in Calpain-1 Activity in the Trabecular Meshwork, Optic Nerve and Implications for Therapeutics [PDF]

CNS & Neurological Disorders - Drug Targets, 2008
Glaucoma is a group of irreversible blinding eye diseases affecting over 70 million people worldwide. Systemic delivery of calpain-1 inhibitors was proposed as a neuroprotection strategy for the prevention of progressive optic nerve damage in glaucoma. We present a general review of calpain-1 and an account of vast differences in processing of calpain ...
Bharathi, Govindarajan, James, Laird, Ronald, Sherman, Robert G, Salomon, Sanjoy K, Bhattacharya   +4 more
openaire   +2 more sources

Calpain 1 and 2 Are Required for RNA Replication of Echovirus 1 [PDF]

Journal of Virology, 2008
ABSTRACTCalpains are calcium-dependent cysteine proteases that degrade cytoskeletal and cytoplasmic proteins. We have studied the role of calpains in the life cycle of human echovirus 1 (EV1). The calpain inhibitors, including calpeptin, calpain inhibitor 1, and calpain inhibitor 2 as well as calpain 1 and calpain 2 short interfering RNAs, completely ...
Paula, Upla, Varpu, Marjomäki, Liisa, Nissinen, Camilla, Nylund, Matti, Waris, Timo, Hyypiä, Jyrki, Heino   +6 more
openaire   +2 more sources

Association of calpains 1 and 2 with protein kinase C activities [PDF]

FEBS Letters, 1987
Calpains 1 and 2 co‐eluted with protein kinase C activities after hydrophobic (phenyl‐Sepharose) and anion‐exchange (Mono Q) chromatographies of a 100 000 × g supernatant which was defined as cytosol. After centrifugation of the cytosol at 200 000 × g for 16 h, the major part of calpain 1 and of its associated protein kinase C activity was recovered in
Savart, Michel, Belamri, Mohammed, Pallet, Véronique, Ducastaing, André   +3 more
openaire   +2 more sources

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans

Cell Reports, 2016
A CAPN1 missense mutation in Parson Russell Terrier dogs is associated with spinocerebellar ataxia. We now report that homozygous or heterozygous CAPN1-null mutations in humans result in cerebellar ataxia and limb spasticity in four independent pedigrees.
Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B. Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudry   +21 more
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Calpain 1 and Calpastatin expression is developmentally regulated in rat brain [PDF]

Experimental Neurology, 2009
Calpains and caspases are cysteine endopeptidases which share many similar substrates. Caspases are essential for caspase-dependent apoptotic death where calpains may play an augmentive role, while calpains are strongly implicated in necrotic cell death morphologies.
Yanzhang, Li, Vimala, Bondada, Aashish, Joshi, James W, Geddes   +3 more
openaire   +2 more sources

Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]

PLoS ONE, 2015
Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu, Wei Liu, Yu Deng, Tian-Yao Yang, Shu Feng, Zhao-Fa Xu   +5 more
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Calpain-1 Contributes to IgE-Mediated Mast Cell Activation [PDF]

The Journal of Immunology, 2014
Abstract Mast cells play a central role in allergy through secretion of both preformed and newly synthesized mediators. Mast cell mediator secretion is controlled by a complex network of signaling events. Despite intensive studies, signaling pathways in the regulation of mast cell mediator secretion remain incompletely defined.
Zhengli, Wu, Xiaochun, Chen, Fang, Liu, Wei, Chen, Ping, Wu, Adam J, Wieschhaus, Athar H, Chishti, Paul A, Roche, Wei-Min, Chen, Tong-Jun, Lin   +9 more
openaire   +2 more sources

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Cell Discovery, 2023
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of ...
Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello   +9 more
doaj   +1 more source