Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice.
Venkateswaran Subramanian +5 more
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Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [PDF]
Journal of Ginseng Research, 2023 Background: As the major pathophysiological feature of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications.
Fang Zhao, Meili Lu, Hongxin Wang
doaj +2 more sources
Calpain-1: a Novel Antiviral Host Factor Identified in Porcine Small Intestinal Mucus [PDF]
mBio, 2022 The thick mucus layer covering of the intestinal epithelium has received increasing attention, owing to its protective role in intestinal infection. However, the exact mechanisms by which the mucus increases intestinal resistance against viral infection ...
Yuchen Li +7 more
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Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway [PDF]
Journal of Ginseng ResearchBackground: Hypoxic pulmonary hypertension (HPH) is the main pathological change in vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some research results have shown that ginsenoside Rg1 (Rg1) can improve vascular remodeling, but
Chenyang Ran +7 more
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Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition. [PDF]
PLoS ONEExposure to arsenic or sugary drinks can increase the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), although the mechanisms involved and its possible interactions remain unexplored.
Myrian Velasco +5 more
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Activation of calpain-1 in human carotid artery atherosclerotic lesions [PDF]
BMC Cardiovascular Disorders, 2009 Background In a previous study, we observed that oxidized low-density lipoprotein-induced death of endothelial cells was calpain-1-dependent. The purpose of the present paper was to study the possible activation of calpain in human carotid plaques, and ...
Pedro Luis M +7 more
doaj +3 more sources
Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 [PDF]
HaematologicaConnexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels.
Kirk A. Taylor +7 more
doaj +2 more sources
Changes in neurodegeneration-related miRNAs in brains from CAPN1−/− mice
BBA Advances, 2021 Calpain-1 knock-out (KO) mice exhibit enhanced susceptibility to neurodegeneration due to the lack of the neuroprotective function of calpain-1. Dicer has been shown to play a fundamental role in the biogenesis of most miRNAs.
Wenyue Su +3 more
doaj +1 more source
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. [PDF]
PLoS ONE, 2012 Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on
Daniela M Santos +4 more
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Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. [PDF]
PLoS ONE, 2008 Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial
Liqun Jiang +7 more
doaj +1 more source