Formation of the calpain-1/calpastatin complex promotes activation of calpain-1 under oxidizing conditions. [PDF]
J Anim SciAbstract Calpains are cysteine proteinases responsible for many biological roles in muscle, including protein degradation, muscle growth, and myoblast fusion. Calpains are inhibited by calpastatin, an endogenous inhibitor. Other factors, such as variations in pH, ionic strength, and oxidation influence calpain activity.
Maddock Carlin KR +3 more
europepmc +4 more sources
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition [PDF]
Heliyon, 2023 Background: Previous studies have demonstrated the beneficial effect of baicalin on pulmonary arterial hypertension (PAH), but the mechanism is unclear.
He-xi Jiang +3 more
doaj +2 more sources
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway [PDF]
Neural Plasticity, 2022 Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases.
Yan Meng +8 more
doaj +2 more sources
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [PDF]
Journal of Ginseng Research, 2023 Background: As the major pathophysiological feature of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications.
Fang Zhao, Meili Lu, Hongxin Wang
doaj +2 more sources
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Xiaoning Bi +2 more
exaly +3 more sources
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. [PDF]
PLoS ONE, 2015 We have recently demonstrated that in resting conditions calpain 1, but not calpain 2, is specifically associated to the N-Methyl-D-Aspartate receptor (NMDAR) multiprotein complex.
Monica Averna +8 more
doaj +5 more sources
Calpain-1: a Novel Antiviral Host Factor Identified in Porcine Small Intestinal Mucus [PDF]
mBio, 2022 The thick mucus layer covering of the intestinal epithelium has received increasing attention, owing to its protective role in intestinal infection. However, the exact mechanisms by which the mucus increases intestinal resistance against viral infection ...
Yuchen Li +7 more
doaj +2 more sources
Ginsenoside Rg1 alleviates vascular remodeling in hypoxia-induced pulmonary hypertension mice through the calpain-1/STAT3 signaling pathway [PDF]
Journal of Ginseng ResearchBackground: Hypoxic pulmonary hypertension (HPH) is the main pathological change in vascular remodeling, a complex cardiopulmonary disease caused by hypoxia. Some research results have shown that ginsenoside Rg1 (Rg1) can improve vascular remodeling, but
Chenyang Ran +7 more
doaj +2 more sources
Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration [PDF]
Trends in Neurosciences, 2016 Many signaling pathways participate in both synaptic plasticity and neuronal degeneration. While calpains participate in these phenomena, very few studies have evaluated the respective roles of the two major calpain isoforms in the brain, calpain-1 and calpain-2.
Xiaoning Bi, Michel Baudry
exaly +3 more sources
Sucrose but not arsenic induce hepatic steatosis which correlates with calpain-1 inhibition. [PDF]
PLoS ONEExposure to arsenic or sugary drinks can increase the risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD), although the mechanisms involved and its possible interactions remain unexplored.
Myrian Velasco +5 more
doaj +2 more sources