Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death [PDF]
Cells, 2020 Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, in the brain ...
Yubin Wang +3 more
doaj +3 more sources
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. [PDF]
PLoS ONE, 2013 Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice.
Venkateswaran Subramanian +5 more
doaj +4 more sources
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition [PDF]
Heliyon, 2023 Background: Previous studies have demonstrated the beneficial effect of baicalin on pulmonary arterial hypertension (PAH), but the mechanism is unclear.
He-xi Jiang +3 more
doaj +2 more sources
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway [PDF]
Neural Plasticity, 2022 Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases.
Yan Meng +8 more
doaj +2 more sources
Ginsenoside Rg1 ameliorates chronic intermittent hypoxia-induced vascular endothelial dysfunction by suppressing the formation of mitochondrial reactive oxygen species through the calpain-1 pathway [PDF]
Journal of Ginseng Research, 2023 Background: As the major pathophysiological feature of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) is vital for the occurrence of cardiovascular complications.
Fang Zhao, Meili Lu, Hongxin Wang
doaj +2 more sources
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation. [PDF]
PLoS ONE, 2012 Calpains are calcium regulated cysteine proteases that have been described in a wide range of cellular processes, including apoptosis, migration and cell cycle regulation. In addition, calpains have been implicated in differentiation, but their impact on
Daniela M Santos +4 more
doaj +2 more sources
Neurobiology of Disease, 2016 Calpain has been shown to be involved in neurodegeneration, and in particular in retinal ganglion cell (RGC) death resulting from increased intraocular pressure (IOP) and ischemia.
Yubin Wang +2 more
exaly +3 more sources
Neuroprotection in Glaucoma Using Calpain-1 Inhibitors: Regional Differences in Calpain-1 Activity in the Trabecular Meshwork, Optic Nerve and Implications for Therapeutics [PDF]
CNS & Neurological Disorders - Drug Targets, 2008 Glaucoma is a group of irreversible blinding eye diseases affecting over 70 million people worldwide. Systemic delivery of calpain-1 inhibitors was proposed as a neuroprotection strategy for the prevention of progressive optic nerve damage in glaucoma. We present a general review of calpain-1 and an account of vast differences in processing of calpain ...
Bharathi, Govindarajan +4 more
openaire +3 more sources
Calpain-1: a Novel Antiviral Host Factor Identified in Porcine Small Intestinal Mucus [PDF]
mBio, 2022 The thick mucus layer covering of the intestinal epithelium has received increasing attention, owing to its protective role in intestinal infection. However, the exact mechanisms by which the mucus increases intestinal resistance against viral infection ...
Yuchen Li +7 more
doaj +2 more sources
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. [PDF]
PLoS ONE, 2015 We have recently demonstrated that in resting conditions calpain 1, but not calpain 2, is specifically associated to the N-Methyl-D-Aspartate receptor (NMDAR) multiprotein complex.
Monica Averna +8 more
doaj +5 more sources