Results 41 to 50 of about 21,266,386 (226)

μ-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation [PDF]

, 2006
μ- and m-calpain are cysteine proteases requiring micro- and millimolar Ca2+ concentrations for their activation in vitro. Among other mechanisms, interaction of calpains with membrane phospholipids has been proposed to facilitate their activation by ...
Machleidt, Werner, Assfalg-Machleidt, Irmgard, Fernández-Montalván, Amaury, Pfeiler, Dietmar, Jochum, Marianne, Fritz, Hans   +5 more
core   +1 more source

Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin [PDF]

, 2003
Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY.
Dominga Deluca, Schaschke, N., Gil-Parrado, S, Werner M.a.c.h.l.e.i.d.t., Luis Moroder, Dietmar Pfeiler, Irmgard Assfalg Machleidt, Machleidt, Werner, Fiorino, F, Pfeiler, D., Pfeiler, D, Machleidt, W, Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Moroder, L, Deluca, D, Gil-Parrado, S., Moroder, L., Machleidt, W., Fiorino, F., Assfalg-Machleidt, I, Norbert Schaschke, Deluca, D., Assfalg-Machleidt, I., FIORINO, FERDINANDO, Shirley Gil Parrado   +25 more
core   +1 more source

Calpain-1: investigating its role in murine neutrophils [PDF]

Neutrophils are phagocytic white blood cells which act as the first line of defence against entry of foreign microorganisms. Neutrophils are recruited to their target site through the process of spreading, extravasation and phagocytosis involving complex signal transduction within the cells, which might include the activation of the cytosolic Ca2 ...
Ishak, Reezal
openaire   +1 more source

Calpain 1 and 2 Are Required for RNA Replication of Echovirus 1 [PDF]

Journal of Virology, 2008
ABSTRACTCalpains are calcium-dependent cysteine proteases that degrade cytoskeletal and cytoplasmic proteins. We have studied the role of calpains in the life cycle of human echovirus 1 (EV1). The calpain inhibitors, including calpeptin, calpain inhibitor 1, and calpain inhibitor 2 as well as calpain 1 and calpain 2 short interfering RNAs, completely ...
Paula, Upla, Varpu, Marjomäki, Liisa, Nissinen, Camilla, Nylund, Matti, Waris, Timo, Hyypiä, Jyrki, Heino   +6 more
openaire   +2 more sources

Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]

, 2001
Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Mentele, Reinhard, Hinz, Heide, Machleidt, Werner, Assfalg-Machleidt, Irmgard, Gabrijelcic-Geiger, Dusica, Auerswald, Ennes A., Möller, Achim, Meisel, Barbara   +7 more
core   +1 more source

Calpain system protein expression and activity in ovarian cancer [PDF]

, 2019
Purpose: Expression of members of the calpain system are associated with clinical outcome of patients with, amongst others, breast and ovarian cancer, with calpain-2 expression in ovarian cancer being implicated in chemo-resistance and survival.
Nicholls, Holly, Zhang, Siwei, Chondrou, Panagiota S., Rungsakaolert, Ployphailin, Martin, Stewart G., Yao, Anqi, Storr, Sarah J., Deen, Suha   +7 more
core   +1 more source

Association of calpains 1 and 2 with protein kinase C activities [PDF]

FEBS Letters, 1987
Calpains 1 and 2 co‐eluted with protein kinase C activities after hydrophobic (phenyl‐Sepharose) and anion‐exchange (Mono Q) chromatographies of a 100 000 × g supernatant which was defined as cytosol. After centrifugation of the cytosol at 200 000 × g for 16 h, the major part of calpain 1 and of its associated protein kinase C activity was recovered in
Savart, Michel, Belamri, Mohammed, Pallet, Véronique, Ducastaing, André   +3 more
openaire   +2 more sources

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts [PDF]

, 2004
Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by ...
Speth, Maria, Deibele, Karin, Neuhof, Heinz, Lubisch, Wilfried, Möller, Achim, Neuhof, Christiane, Fabiunke, Verena, Fritz, Hans, Tillmanns, Harald   +8 more
core   +1 more source

Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts [PDF]

, 2008
The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first ...
Speth, Maria, Erdogan, Ali, Neuhof, Heinz, Neuhof, Christiane, Fabiunke, Verena, Fritz, Hans, Moeller, Achim, Tillmanns, Harald   +7 more
core   +1 more source

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans

Cell Reports, 2016
A CAPN1 missense mutation in Parson Russell Terrier dogs is associated with spinocerebellar ataxia. We now report that homozygous or heterozygous CAPN1-null mutations in humans result in cerebellar ataxia and limb spasticity in four independent pedigrees.
Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B. Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudry   +21 more
doaj   +1 more source