Results 51 to 60 of about 29,724,597 (193)

Deciphering calpain-1 localization and activation: novel insights into postmortem proteolysis and meat tenderization

Food Production, Processing and Nutrition
The objective of this study was to investigate localization and activation of calpain-1 in chicken muscles postmortem and its contribution to meat tenderization. Results showed that plasma membrane bound and sarcoplasmic calpain-1 content increased early
Muhan Zhang, Suhuan Wei, Jiahui Chen, Weimin Xu, Daoying Wang, Huan Bian, Jiaolong Li, Ruirui Guo, Xue Du, Hongjing He   +9 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice [PDF]

, 2010
The motor axonal variant of Guillain-Barré syndrome is associated with anti-GD1a immunoglobulin antibodies, which are believed to be the pathogenic factor. In previous studies we have demonstrated the motor terminal to be a vulnerable site.
Halstead, S., Furukawa, K., Humphreys, P.D, Willison, H.J., McGonigal, R., Rowan, E.G., Greenshields, K.N, Rother, R.P   +7 more
core   +2 more sources

Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. [PDF]

PLoS ONE, 2010
T cell activation and immune synapse formation require the appropriate activation and clustering of the integrin, LFA-1. Previous work has reported that the calpain family of calcium-dependent proteases are important regulators of integrin activation and
Sarah A Wernimont, William T N Simonson, Peter A Greer, Christine M Seroogy, Anna Huttenlocher   +4 more
doaj   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes. [PDF]

PLoS ONE, 2010
The immune cells named T lymphocytes circulate around the body fulfilling their role in immunosurveillance by monitoring the tissues for injury or infection.
Lena Svensson, Alison McDowall, Katherine M Giles, Paula Stanley, Stefan Feske, Nancy Hogg   +5 more
doaj   +1 more source

Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg, Cecilia Fugmann, Juliana Imgenberg‐Kreuz   +2 more
wiley   +1 more source

Effects of Yam and Diosgenin on Calpain Systems in Skeletal Muscle of Ovariectomized Rats

Taiwanese Journal of Obstetrics & Gynecology, 2008
Objective: Yam or diosgenin (extracted from the root of wild yam) is traditionally used for hormone replacement in menopausal women. Calpains are crucially related to the degradation of myofibrillar proteins in skeletal muscle.
Kung-Hao Hsu, Chi-Chen Chang, Horng-Der Tsai, Fuu-Jen Tsai, Yao-Yuan Hsieh   +4 more
doaj   +1 more source

Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain

Frontiers in Genetics, 2020
Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in organs and ...
Wenyue Su, Qian Zhou, Qian Zhou, Yubin Wang, Athar Chishti, Qingshun Q. Li, Qingshun Q. Li, Sujay Dayal, Shayan Shiehzadegan, Ariel Cheng, Clare Moore, Xiaoning Bi, Michel Baudry   +12 more
doaj   +1 more source