Results 71 to 80 of about 29,724,597 (193)
Pharmacological ResearchSPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The encoded protein, calpain 1, is a calcium-activated cysteine protease that catalyzes the proteolytic cleavage of a variety of cellular ...
Francesca Brivio +6 more
doaj +1 more source
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family
Frontiers in Neurology, 2019 CAPN1 encodes calpain-1, a large subunit of μ-calpain, a calcium-activated cysteine protease widely present in the central nervous system. Mutations in CAPN1 have recently been identified in a complicated form of Hereditary Spastic Paraplegia (HSP) with ...
Stefano Cotti Piccinelli +12 more
doaj +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
iNew Medicine, EarlyView.This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin +10 more
wiley +1 more source
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Elevated calpain protein in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.
, 2013 Calpain-1 (A) and calpain-2 (B) proteins were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days.
Venkateswaran Subramanian (447896) +5 more
core +1 more source
Regulation of calpain-1 signaling in platelets.
, 2008 Regulation of calpain-1 signaling in ...
Shafi M. Kuchay (7954067)
core +6 more sources
Revisiting the calpain hypothesis of learning and memory 40 years later
Frontiers in Molecular NeuroscienceIn 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the ...
Michel Baudry, Xiaoning Bi
doaj +1 more source
Calpain inhibition ameliorates scald burn-induced acute lung injury in rats
Burns & Trauma, 2018 Background The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown.
Peng-Ran Du +8 more
doaj +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Diet‐induced inflammation is a major cause of muscle degeneration impacting human and animal health. Owing to their anti‐inflammatory and antioxidant properties, polyphenols have attracted considerable interest as feed additives.
Graziella Orso +8 more
wiley +1 more source