Results 71 to 80 of about 21,266,386 (226)

Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

Molecular Brain, 2017
Memory consolidation, reconsolidation, and extinction have been shown to share similar molecular signatures, including new gene expression. Calpain is a Ca2+-dependent protease that exerts its effects through the proteolytic cleavage of target proteins ...
Taikai Nagayoshi, Kiichiro Isoda, Nori Mamiya, Satoshi Kida   +3 more
doaj   +1 more source

Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain

Frontiers in Genetics, 2020
Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in organs and ...
Wenyue Su, Qian Zhou, Qian Zhou, Yubin Wang, Athar Chishti, Qingshun Q. Li, Qingshun Q. Li, Sujay Dayal, Shayan Shiehzadegan, Ariel Cheng, Clare Moore, Xiaoning Bi, Michel Baudry   +12 more
doaj   +1 more source

Deimination of Human Filaggrin-2 Promotes Its Proteolysis by Calpain 1 [PDF]

Journal of Biological Chemistry, 2011
Filaggrin-2 (FLG2), a member of the S100-fused type protein family, shares numerous features with filaggrin (FLG), a key protein implicated in the epidermal barrier functions. Both display a related structural organization, an identical pattern of expression and localization in human epidermis, and proteolytic processing of a large precursor.
Chiung-Yueh, Hsu, Julie, Henry, Anne-Aurélie, Raymond, Marie-Claire, Méchin, Valérie, Pendaries, Dany, Nassar, Britta, Hansmann, Stéfana, Balica, Odile, Burlet-Schiltz, Anne-Marie, Schmitt, Hidenari, Takahara, Carle, Paul, Guy, Serre, Michel, Simon   +13 more
openaire   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Effects of Yam and Diosgenin on Calpain Systems in Skeletal Muscle of Ovariectomized Rats

Taiwanese Journal of Obstetrics & Gynecology, 2008
Objective: Yam or diosgenin (extracted from the root of wild yam) is traditionally used for hormone replacement in menopausal women. Calpains are crucially related to the degradation of myofibrillar proteins in skeletal muscle.
Kung-Hao Hsu, Chi-Chen Chang, Horng-Der Tsai, Fuu-Jen Tsai, Yao-Yuan Hsieh   +4 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Calpain-mediated degradation of GFAP at 2 h following blast injury.

, 2017
Proteins were isolated from sham control (Sham), low-blast (L-Blast), and high-blast (H-Blast) OHCs at 2 h post-injury and analyzed via western blot for expression of GFAP (A, B) or calpain (C).
Brandy V. Aperi (3815545), Anna P. Miller (3815539), Shekar N. Kurpad (2556643), Aleksandra Glavaski-Joksimovic (3815542), Alok S. Shah (729610), Brian D. Stemper (729612)   +5 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Scientific Reports, 2022
Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for excitation ...
Gunnar Weninger, Tatiana Pochechueva, Dana El Chami, Xiaojing Luo, Tobias Kohl, Sören Brandenburg, Henning Urlaub, Kaomei Guan, Christof Lenz, Stephan E. Lehnart   +9 more
doaj   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source