Results 91 to 100 of about 21,266,386 (226)

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Revisiting the calpain hypothesis of learning and memory 40 years later

Frontiers in Molecular Neuroscience
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the ...
Michel Baudry, Xiaoning Bi
doaj   +1 more source

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

Burns & Trauma, 2018
Background The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown.
Peng-Ran Du, Hong-Ting Lu, Xi-Xiang Lin, Li-Feng Wang, Yan-Xia Wang, Xiao-Ming Gu, Xiao-Zhi Bai, Ke Tao, Jing-Jun Zhou   +8 more
doaj   +1 more source

Mitochondrial calpain-1 truncates ATP synthase beta subunit

Biochemical and Biophysical Research Communications
Calpains cleave proteins in a calcium concentration-dependent manner, modulating their intracellular functions. Calpain-1, a member of the calpain family, is localized in the cytosol and mitochondria. Mitochondrial calpain-1 induces mitochondrial dysfunction and apoptosis by cleaving its substrate.
Yusaku Chukai, Nanami Furukawa, On Kosegawa, Lanlan Bai, Eriko Sugano, Tomokazu Fukuda, Hiroshi Tomita, Taku Ozaki   +7 more
openaire   +2 more sources

Activation of Mitochondrial Calpain 1 Leads to Degradation of PDH

The FASEB Journal, 2018
INTODUCTION Calpain 1 (CPN1) is a ubiquitous calpain including one large subunit and a small regulatory subunit (calpain 4, CPN4). Genetic removal of CPN4 eliminates the CPN1 activity. CPN1 exists in both cytosol and mitochondria.
Qun Chen, Jeremy Thompson, Ying Hu, John Hollander, Edward Lesnefsky   +4 more
openaire   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Elevated calpain activity in AngII infused calpain-1 +/+ and calpain-1 −/− aortas.

, 2013
Spectrin breakdown products (A) were detected by Western blotting in tissue extracts from aortas in calpain-1 +/+ x LDL receptor −/− and calpain-1 −/− x −/− LDL receptor −/− mice infused with either saline or AngII for 7 days as a measure of calpain ...
Venkateswaran Subramanian (447896), Haruhito A. Uchida (447898), Athar H. Chishti (447897), Jessica J. Moorleghen (113038), Anju Balakrishnan (113044), Deborah A. Howatt (113047)   +5 more
core   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Characterizing the Catalytic Action of μ-Calpain on Myofibrillar Protein Structure

, 2006
Solving the problem of inconsistent meat tenderness is a top priority of the meat industry. This requires a greater understanding of the processes that affect meat tenderness and the adoption of such information by the meat industry. It is essential that
Fraser-Smith, Emma Louise
core  

Transcriptomic profiling of gill biopsies to define predictive markers for seawater survival in farmed Atlantic salmon

Journal of Fish Biology, EarlyView.
Abstract Wild Atlantic salmon migrate to sea following completion of a developmental process known as parr‐smolt transformation (PST), which establishes a seawater (SW) tolerant phenotype. Effective imitation of this aspect of anadromous life history is a crucial aspect of commercial salmon production, with current industry practice being marred by ...
Lars Grønvold, Mattis J. van Dalum, Anja Striberny, Domniki Manousi, Trine Ytrestøyl, Turid Mørkøre, Solomon Boison, Bjarne Gjerde, Even Jørgensen, Simen R. Sandve, David G. Hazlerigg   +10 more
wiley   +1 more source