Results 101 to 110 of about 26,728 (182)

hUC‐MSCs via β‐NGF Alleviate Cognitive Impairment After Tibial Fracture Surgery by Regulating the STMN2/NMNAT2‐SARM1‐NF‐κB Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
This study found that human umbilical cord mesenchymal stem cells secrete β‐NGF, which binds to the TrkA receptor on neurons, upregulates the protein levels of STMN2 and NMNAT2 in mice with perioperative neurocognitive disorders, and thereby downregulates the protein levels of SARM1 and p‐NF‐κB.
Kai Wang, Fangjun Wang, Yuhan Zhang, Wenbo Li, Shuai Li, Ying Zhou, Guangkuo Ma, Ziwei Xia, Xueyan Zhou, Liwei Wang   +9 more
wiley   +1 more source

Engineered exosomes improve myocardial cell membrane integrity and heart function in dystrophic cardiomyopathy

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Schematic diagram of the manufacturing process of exosomes‐cardiac homing peptide (Exo‐CHP) and its therapeutic effects for Duchenne muscular dystrophy (DMD) cardiomyopathy. Abstract Background Duchenne muscular dystrophy (DMD)‐associated cardiomyopathy is a leading causes of premature death, yet treatment options remain limited.
Qihong Wu, Yiyuan Xue, Kun Zhang, Ke Xu, Ting Xu, Hang Fu, Suming Zhang, Meng Zhang, Ran Sun, Sophelia Hoi Shan Chan, Linyuhan Zhou, Xiaotang Cai, Yingkun Guo, Huayan Xu   +13 more
wiley   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62

Haematologica
Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels.
Kirk A. Taylor, Amro Elgheznawy, Recep Adiyaman, Tyler L. Horn, Sarah Parkes, Craig E. Hughes, Liam J. McGuffin, Jonathan M. Gibbins   +7 more
doaj   +1 more source

A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells

Kidney Research and Clinical Practice, 2017
Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
doaj   +1 more source

Inhibiting HIF‐1α‐Induced miR‐663b Improves Pulmonary Arterial Hypertension by Reducing Dysfunctions of PASMCs Through Repressing Sirt1‐ZBP1‐Mediated PANoptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive disease characterised by vascular remodelling. Inflammatory responses and oxidative stress have been shown to contribute to its progression. This study investigated the effects of a novel HIF‐1α‐miR‐663b axis on pulmonary arterial smooth muscle inflammation, oxidative stress and apoptosis ...
Le Shen, Honghong Ma, Yang Yu, Yan Xu, Qun Yuan, Xia Zhao, Bing Zhuan   +6 more
wiley   +1 more source

The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol‐induced hypertrophy in rat cardiac muscle cells by down‐regulating miR‐183‐5p

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract The Cavβ4 subunit of voltage‐gated Cav1.2 channels regulates gene expression in neurons and cardiac cells. It increases the expression of interferon‐β–related genes in H9c2 cardiomyocytes derived from rat ventricular tissue, but the possibility that it also regulates the expression of microRNAs (miRs) remains unexplored.
Elba D. Carrillo, Erick Galicia, María C. García, Jorge A. Sánchez   +3 more
wiley   +1 more source

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

The Correlation of Serum Calpain 1 Activity and Concentrations of Interleukin 33 in COVID-19 Acute Respiratory Distress Syndrome. [PDF]

Biomedicines, 2023
Loinjak D, Mihić D, Smolić R, Maričić L, Šahinović I, Smolić M, Sikora R, Loinjak S, Dinjar K, Včev A.   +9 more
europepmc   +1 more source

Calpain 1 (CAPN1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source