Results 121 to 130 of about 21,266,386 (226)
, 2000 Calpains play important roles in numerous physiological and pathological processes (1,2) by catalyzing the limited proteolysis of a wide variety of protein substrates.
Guttmann, Rodney P. (author) +1 more
core
Calpain 1 in neurodegeneration: a therapeutic target? [PDF]
The Lancet Neurology, 2016 Ziv, Gan-Or, Guy A, Rouleau
openaire +2 more sources
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1129-1140, June 2026.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Proteomic investigation of the class IA phosphoinositide 3-kinase signalling pathway
, 2012 PhDClass IA phosphoinositide 3-kinases (PI3Ks) are a family of enzymes with key roles in the regulation of signalling pathways, many of which are mediated through Akt.
Beltran, Luisa
core
Advanced Science, Volume 13, Issue 34, 19 June 2026.We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li +10 more
wiley +1 more source
Calpain inhibition stimulates caspase-dependent apoptosis induced by taxol in NIH3T3 cells
, 2007 Taxol is an anticancer drug that triggers apoptosis in a wide spectrum of cancers such as ovarian, breast, lung, head and neck, and bladder carcinoma by both caspase-dependent and -independent apoptosis mechanisms.
Salinas, Matilde +4 more
core +1 more source
Kidney Research and Clinical Practice, 2017 Background: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ.
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou +7 more
wiley +1 more source
, 2019 以前より腫瘍細胞が血小板凝集能を惹起し,血行性転移における遠隔臓器の血管内皮への接着に重要な役割を果たすと考えられているが,その分子メカニズムについて不明な点も多い。そこで本研究では,カルシウム依存性細胞内システインプロテアーゼであるcalpain に着目し,癌転移におけるcalpain の役割について検討を行った。B16/BL6メラノーマ細胞株,colon-26直腸がん由来細胞株の遊走能,浸潤能はコントロールと比較しcalpain 阻害剤,ALLN 添加により有意に抑制された ...
二宮, 治彦 +4 more
core
Interaction between calpain and HSP90.
, 2015 (A) Purified calpain-1 or-2 (1.5 µg) was incubated for 1 hour at 25°C with the indicated amounts of purified HSP90. Immunoprecipitation was carried out using 1 µg of anti-HSP90 antibody.
Sandro Pontremoli (309270) +7 more
core +1 more source