Results 131 to 140 of about 21,266,386 (226)

Host immune collapse in influenza‐associated pulmonary aspergillosis: From barrier dysfunction to metabolic paralysis

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
From barrier dysfunction to metabolic paralysis: IAPA progression is characterized by a functional dissociation: the host experiences hyper‐inflammatory cytokine storms (IL‐1β, IFN‐λ) while simultaneously suffering from antimicrobial metabolic paralysis (loss of ROS and recognition). This creates a specific window for host‐directed therapies, including
Liangyu Li, Shuo Liang
wiley   +1 more source

Stabilization of calpain large subunits by overexpression of truncated calpain small subunit in L8 myoblasts.

, 2010
[[abstract]]The objectives were to investigate the function of the small subunit in the calpain system by expression of the autolytic form of this subunit in L8 myoblasts.
Chung, T. C.;Liang, Y. C.;Yeh, J. Y.;Ou, B. R.
core  

Exploring the Unique and Shared Proteolytic Properties of Calpain-1 and Calpain-2

Calpain-1 (µ-calpain) and calpain-2 (m-calpain) are ubiquitous Ca²⁺-dependent cysteine proteases with overlapping and divergent roles in human cells that remain incompletely defined.
Bulluss, Mitchell
core   +1 more source

Calpain-1 : investigating its role in murine neutrophils [PDF]

, 2012
Neutrophils are phagocytic white blood cells which act as the first line of defence against entry of foreign microorganisms. Neutrophils are recruited to their target site through the process of spreading, extravasation and phagocytosis involving complex
Ishak, Reezal
core  

Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development

, 2018
Background: With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs.
이정현, 최선
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Honokiol activates calpain activity.

, 2013
Calpain activity was measured with the fluorescent calpain substrate Suc-LLVY-AMC in N87, AGS, MKN45 and SCM-1 cells. (A) Time course responses to honokiol (20 µM) treatment. Data are expressed in terms of fold of control conditions. (B) Honokiol (20 and
Keng Hsin Lan (80696), Shing Hwa Liu (38213), Meei Ling Sheu (80695)   +2 more
core   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62

Haematologica
Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels.
Kirk A. Taylor, Amro Elgheznawy, Recep Adiyaman, Tyler L. Horn, Sarah Parkes, Craig E. Hughes, Liam J. McGuffin, Jonathan M. Gibbins   +7 more
doaj   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source