Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models [PDF]
, 2019 Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer.
Rodríguez Fernández, Lucía
core
Fibrosis resolution in the mouse liver: Role of Mmp12 and potential role of calpain 1/2. [PDF]
Matrix Biol Plus, 2023 Sato T +13 more
europepmc +1 more source
Identification and neuroprotective properties of NA‐184, a calpain‐2 inhibitor
Pharmacology Research & PerspectivesOur laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotective and calpain‐1 ...
Michel Baudry +14 more
doaj +1 more source
Regulation of calpain-1 signaling in platelets.
, 2008 Regulation of calpain-1 signaling in ...
Shafi M. Kuchay (7954067)
core
Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1. [PDF]
Oncoimmunology, 2022 Lin D +11 more
europepmc +1 more source
TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets [PDF]
, 2016 Several neurological conditions share a characteristic feature: an increase in intracellular calcium levels ([Ca2+]i). It has been demonstrated that calcium influx induces changes ranging from an increase in the expression levels of several genes to ...
Danelon, Víctor +2 more
core
Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension. [PDF]
J Cell Mol Med, 2022 Deng H +5 more
europepmc +1 more source
Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy
Diabetes, Metabolic Syndrome and Obesity, 2019 Tao Wang,1 Yanbin Gao,1,2 Xiaolei Wang,1 Yimin Shi,1 Jiayi Xu,1 Bingjie Wu,1 Jiaxin He,1 Yimeng Li2 1School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of TCM Collateral ...
Wang T +7 more
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