Results 151 to 160 of about 29,724,597 (193)

Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway. [PDF]

Front Pharmacol, 2022
Zhao F, Meng Y, Wang Y, Fan S, Liu Y, Zhang X, Ran C, Wang H, Lu M.   +8 more
europepmc   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, Volume 604, Issue 17, Page 7246-7263, 1 September 2026.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source

Long‐term imoxin treatment does not attenuate disease severity in dystrophic diaphragm of male mice

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Duchenne muscular dystrophy (DMD) is characterized by chronic skeletal muscle injury and degeneration. We discovered activation of protein kinase R (PKR; EIF2AK2), a regulator of the integrated stress response, in dystrophic muscle; however, its role in DMD remains unknown.
Ji Heun Lee, Morgan E. Vorwald, Melissa Roths, Joshua T. Selsby, Rudy J. Valentine   +4 more
wiley   +1 more source

Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research? [PDF]

Cells
Baudry M, Bi X.
europepmc   +1 more source

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice. [PDF]

Cell Mol Life Sci, 2022
Companys-Alemany J, Turcu AL, Schneider M, Müller CE, Vázquez S, Griñán-Ferré C, Pallàs M.   +6 more
europepmc   +1 more source

Calpain-1 Potentiates Periodontal Regeneration via PHLPP1-ERK-Driven Osteogenesis in Periodontal Ligament Stem Cells. [PDF]

Int Dent J
Li Y, Yang B, Mei Z, Deng P, Fu T, Li J.
europepmc   +1 more source

Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis. [PDF]

Oxid Med Cell Longev, 2022
Shen F, Xie P, Li C, Bian Z, Wang X, Peng D, Zhu G.   +6 more
europepmc   +1 more source

Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches [PDF]

Due to breast cancer’s aggressive behavior and lack of effective targeted therapies once it becomes metastatic, it remains a leading cause of cancer mortality among women.
Shapovalov, Ivan
core  

Subtype-specific divergent roles of calpain-1 and calpain-2 in basal A triple-negative breast cancer. [PDF]

BMC Mol Cell Biol
Üner G, Bedir E, Kirmizibayrak PB.
europepmc   +1 more source

Genetic polymorphisms influencing meat productivity and quality in Kalmyk cattle of Russia: A systematic review of growth hormone, thyroglobulin, leptin, and calpain-1 genes. [PDF]

Vet World
Chimidova N, Ubushieva A, Ubushieva V, Bochkaeva Z.   +3 more
europepmc   +1 more source