Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. [PDF]
Basic Res Cardiol, 2022 Liu X +8 more
europepmc +1 more source
Calpain-1 inhibition attenuates in vivo thrombosis in a humanized model of sickle cell disease. [PDF]
Thromb Res, 2022 Mithila F +8 more
europepmc +1 more source
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy. [PDF]
Biochem J, 2021 Wang J +8 more
europepmc +1 more source
MALAT1 may regulate hERG channel density by stabilizing calpain-1, providing new insights into the adverse effects of cardiotoxic drugs or pathological conditions.
Yuexin Li (18407946)
core +1 more source
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation. [PDF]
EMBO RepPark DH +7 more
europepmc +1 more source
Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway. [PDF]
Front Pharmacol, 2022 Zhao F +8 more
europepmc +1 more source
A Compound Heterozygous Mutation in Calpain 1 Identifies a New Genetic Cause for Spinal Muscular Atrophy Type 4 (SMA4). [PDF]
Front Genet, 2021 Perez-Siles G +8 more
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The roles of calpain and protein kinase C in type 1 diabetic vascular dysfunction
, 2010 Endothelial dysfunction is an early change associated with cardiovascular disease in diabetes. The calcium-dependent protease calpain is activated in the endothelium by acute hyperglycemia and type 2 diabetes.
Smolock, Amanda R
core
NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice. [PDF]
Cell Mol Life Sci, 2022 Companys-Alemany J +6 more
europepmc +1 more source
Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research? [PDF]
CellsBaudry M, Bi X.
europepmc +1 more source